ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Essential role of osterix for tooth root but not crown dentin formation.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- SLIT3: a novel regulator of odontogenic differentiation through Akt/GSK3β/β-catenin signaling pathway.International journal of oral science · 2026Article
- Inhibition of histone deacetylase 3 in dental mesenchyme regulates the development of tooth root.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Novel Roles of Nestin in Postnatal Root Formation.Dentistry journal · 2025Article
- Bone or Tooth dentin: The TGF-β signaling is the key.International journal of biological sciences · 2024Article
- Expression of secretory calcium-binding phosphoprotein (scpp) genes in medaka during the formation and replacement of pharyngeal teeth.BMC oral health · 2023Article
- Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation.International journal of oral science · 2023Article
- SP7: from Bone Development to Skeletal Disease.Current osteoporosis reports · 2023Review
- Constitutive expression of spliced X-box binding protein 1 inhibits dentin formation in mice.Frontiers in physiology · 2023Article
- BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications.Frontiers in cell and developmental biology · 2023Review
- Diverse stem cells for periodontal tissue formation and regeneration.Genesis (New York, N.Y. : 2000) · 2022Review
- Review
- Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice.Stem cell research & therapy · 2022Article
- Genome-scale actions of master regulators directing skeletal development.The Japanese dental science review · 2021Review
- Transforming Growth Factor-β Signaling Regulates Tooth Root Dentinogenesis by Cooperation With Wnt Signaling.Frontiers in cell and developmental biology · 2021Article
- Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.Frontiers in physiology · 2021Article
- Osteocytes but not osteoblasts directly build mineralized bone structures.International journal of biological sciences · 2021Article
- Allogeneic Fibrin Clot for Odontogenic/Cementogenic Differentiation of Human Dental Mesenchymal Stem Cells.Tissue engineering and regenerative medicine · 2020Article
- Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP.Journal of dental research · 2020Article
- Article
- Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Tooth is made of crown and root. It is widely believed that dentin formation in crown and root uses the same regulatory mechanism. However, identification of nuclear factor 1 C (NFIC)'s unique function in determining root but not crown dentin formation challenges the old thinking. In searching for the target molecules downstream of NFIC, we unexpectedly found a sharp reduction of osterix (OSX), the key transcription factor in skeleton formation, in the Nfic knockout (Nfic-KO) tooth root. We then demonstrated a dose-dependent increase of Osx in the odontoblast cell line due to a transient transfection of Nfic expression plasmid. Studies of global and conditional Osx-KO mice revealed no apparent changes in the crown dentin tubules and dentin matrix. However, the OSX conditional KO (cKO) mice (crossed to the 2.3-kb collagen type 1 [Col1]-Cre) displayed an increase in cell proliferation but great decreases in expressions of root dentin matrix proteins (dentin matrix protein 1 [DMP1] and dentin sialophosphoprotein [DSPP]), leading to an inhibition in odontoblast differentiation, and short, thin root dentin with few dentin tubules. Compared to the Nfic-KO tooth, which contains essentially no dentin tubules and remains in a "root-less" status at adult stages, the Osx-cKO root phenotype had partially improved at the late stage, indicating that other factors can compensate for OSX function. Thus, we conclude that OSX, one of the key downstream molecules of NFIC, plays a critical role in root, but not crown, formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.