Evidence map›Paper›PMID 25349058›Full record

Trial reportInternational journal of obesity (2005)2015

Diet-induced weight loss has chronic tissue-specific effects on glucocorticoid metabolism in overweight postmenopausal women.

A Stomby, K Simonyte, C Mellberg, M Ryberg, R H Stimson, C Larsson, B Lindahl, R Andrew, B R Walker, T Olsson

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Pooled it
  5. Pooled it
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  7. Trial
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  9. Review
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  15. Reply to X Chen et al.Advances in nutrition (Bethesda, Md.) · 2020
    Article
  16. Article
  17. Review
  18. Review
  19. Increased Cortisol and Cortisone Levels in Overweight Children.Medical science monitor basic research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

A StombyDepartment for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
K SimonyteDepartment for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
C MellbergDepartment for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
M RybergDepartment for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
R H StimsonBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.
C Larsson1] Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden [2] Department of Food and Nutrition, Umeå University, Umeå, Sweden.
B LindahlDepartment for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
R AndrewBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.
B R WalkerBHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland.
T Olsson1] Department for Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden [2] Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa.
Umeå University · SEUniversity of Edinburgh · GBStellenbosch University · ZAUniversity of Gothenburg · SE

Funding

British Heart Foundation RG/11/4/28734Wellcome Trust
6 · The paper itself

Abstract

BACKGROUND/

objectivesTissue-specific glucocorticoid metabolism is altered in obesity, and may increase cardiovascular risk. This dysregulation is normalized by short-term calorie restriction and weight loss, an effect that varies with dietary macronutrient composition. However, tissue-specific glucocorticoid metabolism has not been studied during long-term (>6 months) dietary interventions. Therefore our aim was to test whether long-term dietary interventions, either a paleolithic-type diet (PD) or a diet according to Nordic nutrition recommendations (NNR) could normalize tissue-specific glucocorticoid metabolism in overweight and obese women. SUBJECTS/

methodsForty-nine overweight/obese postmenopausal women were randomized to a paleolithic diet or a diet according to NNR for 24 months. At baseline, 6 and 24 months anthropometric measurements, insulin sensitivity, excretion of urinary glucocorticoid metabolites in 24-hour collections, conversion of orally administered cortisone to plasma cortisol and transcript levels of 11β hydroxysteroid dehydrogenase type 1 (11βHSD1) in subcutaneous adipose tissue were studied.

resultsBoth diet groups achieved significant and sustained weight loss. Weight loss with the PD was greater than on NNR diet after 6 months (P<0.001) but similar at 24 months. Urinary measurement of 5α-reductase activity was increased after 24 months in both groups compared with baseline (P<0.001). Subcutaneous adipose tissue 11βHSD1 gene expression decreased at 6 and 24 months in both diet groups (P=0.036). Consistent with increased liver 11βHSD1, conversion of oral cortisone to cortisol increased at 6 months (P=0.023) but was unchanged compared with baseline by 24 months.

conclusionsLong-term weight loss in postmenopausal women has tissue-specific and time-dependent effects on glucocorticoid metabolism. This may alter local-tissue cortisol exposure contributing to improved metabolic function during weight loss.

Indexed as

Weight LossWeight Reduction Programs11-beta-Hydroxysteroid Dehydrogenase Type 1Adipose TissueBody Mass IndexCaloric RestrictionCardiovascular DiseasesEnergy IntakeEnergy MetabolismFemaleHumansHydrocortisoneInsulin ResistanceMiddle AgedOverweightPostmenopause11-beta-Hydroxysteroid Dehydrogenase Type 1Hydrocortisone

Identifiers

PMID25349058
OpenAlexW2071941299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.