Evidence map›Paper›PMID 25348842›Full record

ArticlePediatric pulmonology2015

Gender- and age-specific risk factors for wheeze from birth through adolescence.

Sze Man Tse, Brent A Coull, Joanne E Sordillo, Soma Datta, Diane R Gold

Abstract read
In one paragraph

Article in Pediatric pulmonology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Does fetal leptin and adiponectin influence children's lung function and risk of wheeze?Journal of developmental origins of health and disease · 2021
    Article
  6. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood.American journal of respiratory and critical care medicine · 2021
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sze Man TseChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Brent A CoullDepartment of Biostatistics, Harvard School of Public Health, Boston, Massachusett.
Joanne E SordilloChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Soma DattaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Diane R GoldChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The Epidemiology of Home Allergens and AsthmaR01AI035786 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R · 1994 to 2010
$9.5M
The Epidemiology of Home Allergens and AsthmaR56AI035786 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLD, DIANE R · 2011 to 2011
$486k
NIAID NIH HHS R01 AI035786NIAID NIH HHS R56 AI035786NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

BACKGROUND AND

objectiveCross-sectional gender differences in wheeze are well documented, but few studies have examined the gender-specific risk factors for wheeze longitudinally. This study aims to identify gender- and age-specific risk factors for wheeze from birth through adolescence.

methodsThe incidence of wheeze was ascertained every 6 months through age 14 years in a birth cohort consisting of 499 children with a parental history of atopy. Gender- and age-specific risk factors were identified through generalized estimating equations.

resultsA total of 454 (91.0%) and 351 (70.3%) children were followed past age 7 and 13 years, respectively. Maternal asthma was a risk factor for wheeze in girls (OR = 2.05, 95% CI 1.44-2.91, P < 0.0001) and boys (OR = 1.79, 1.29-2.48, P = 0.0004) and had a similar effect on wheeze throughout the ages. Paternal asthma (OR = 1.83, 1.38-2.57, P = 0.0005) and infant bronchiolitis (OR = 2.15, 1.47-3.14, P < 0.0001) were risk factors for boys only, with similar effects throughout the ages.

conclusionUsing a prospective cohort, we identified gender- and age-specific risk factors for wheeze. The identification of gender-specific early life risk factors may allow for timely interventions and a more personalized approach to the treatment of asthma.

Indexed as

AdolescentAge FactorsAsthmaBostonBronchiolitisChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMaleParentsRespiratory SoundsRisk Factorsasthmabronchiolitisparental asthmasex differences

Identifiers

PMID25348842
PMCPMC4800823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.