Trial reportPediatric nephrology (Berlin, Germany)2015
Pediatric reference ranges for acute kidney injury biomarkers.
Trial report in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection.Frontiers in medicine · 2022Pooled it
- The use of urinary biomarkers to predict acute kidney injury in children after liver transplant.Pediatric transplantation · 2020Trial
- A novel strategy for identifying early acute kidney injury in pediatric hematopoietic stem cell transplantation.Bone marrow transplantation · 2019Trial
- Pharmacokinetics and safety of tobramycin nebulization with the I-neb and PARI-LC Plus in children with cystic fibrosis: A randomized, crossover study.British journal of clinical pharmacology · 2019Trial
- Cystatin C as a Renal Biomarker in Infants with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT): A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Adrenal response at the onset of type 1 diabetes mellitus in children and its association with acute metabolic and kidney complications.BMC endocrine disorders · 2025Observational
- The overlooked subgroup: preterm neonates with elevated serum creatinine outside neonatal AKI criteria.Pediatric research · 2025Article
- Determination of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) Reference Intervals in Healthy Adult and Pediatric Individuals Using a Particle-Enhanced Turbidimetric Immunoassay.Diagnostics (Basel, Switzerland) · 2025Article
- Acidosis at Diagnosis of Type 1 Diabetes Mellitus: Relation With Kidney Function.Pediatric diabetes · 2025Article
- Association between lactate dehydrogenase to albumin ratio and acute kidney injury in patients with sepsis: a retrospective cohort study.Clinical and experimental nephrology · 2024Article
- Environmental exposure to melamine and its derivatives and kidney outcomes in children.Environmental research · 2024Article
- Is the urinary neutrophil gelatinase-associated lipocalin concentration in children and adolescents with type 1 diabetes mellitus different from that in healthy children?Biochemia medica · 2024Article
- Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset.Pediatric research · 2023Article
- Associations Between Characteristics of Individuals With Fontan Circulation With Blood and Urine Biomarkers of Kidney Injury and Dysfunction.Journal of the American Heart Association · 2023Article
- Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery: A Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2023Article
- Biomarkers in Pediatric Nephrology-From Bedside to Bench and Back Again.Journal of clinical medicine · 2022Article
- Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Urinary biomarkers indicate pediatric renal injury among rural farming communities in Sri Lanka.Scientific reports · 2022Article
- Urinary cystatin C: pediatric reference intervals and comparative assessment as a biomarker of renal injury among children in the regions with high burden of CKDu in Sri Lanka.World journal of pediatrics : WJP · 2022Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundNovel urinary biomarkers are useful for the prediction of acute kidney injury (AKI). Most promising are the urine markers NGAL, IL-18, KIM-1, and LFABP. Each of these has shown considerable promise diagnosing AKI earlier than serum creatinine (Scr) using disease controls. We set out to determine reference levels of these markers in a healthy pediatric population.
methodsUrine was collected from 368 healthy children and assayed for NGAL, IL-18, KIM-1, and LFABP using commercially available kits or assay materials. Analysis of biomarkers by linear regression and according to age groups (3-<5 years; 5-<10; 10-<15; 15-<18) was performed to determine if biomarker levels differed with age and gender.
resultsMedian values were: NGAL (6.6 ng/ml; IQR 2.8-17), IL-18 (21.6 pg/ml; IQR 13.6-32.9), KIM-1 (410 pg/ml; IQR 226-703), LFABP (3.4 ng/ml; IQR 1.6-6.0). Significant gender differences were found with NGAL and IL-18 and significant age differences were found with all markers. 95th percentile values for each marker varied with age and gender greater than median values.
conclusionsThis is the largest pediatric reference range study for the urinary measurement of NGAL, IL-18, KIM-1, and LFABP and highlights age and gender differences in these markers. This information is essential for rational interpretation of studies and clinical trials utilizing these emerging AKI biomarkers.
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