ArticleJournal of the Association for Research in Otolaryngology : JARO2015
Modeling binaural responses in the auditory brainstem to electric stimulation of the auditory nerve.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.Journal of computational neuroscience · 2025Article
- Rate dependent neural responses of interaural-time-difference cues in fine-structure and envelope.PeerJ · 2024Article
- Simulation of ITD-Dependent Single-Neuron Responses Under Electrical Stimulation and with Amplitude-Modulated Acoustic Stimuli.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Reweighting of Binaural Localization Cues in Bilateral Cochlear-Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Auditory Brainstem Models: Adapting Cochlear Nuclei Improve Spatial Encoding by the Medial Superior Olive in Reverberation.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Effects of rate and age in processing interaural time and level differences in normal-hearing and bilateral cochlear-implant listeners.The Journal of the Acoustical Society of America · 2019Article
- Improved Neural Coding of ITD with Bilateral Cochlear Implants by Introducing Short Inter-pulse Intervals.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Physiological models of the lateral superior olive.PLoS computational biology · 2017Article
- Binaural sensitivity in children who use bilateral cochlear implants.The Journal of the Acoustical Society of America · 2017Article
- Sensitivity to Interaural Time Differences Conveyed in the Stimulus Envelope: Estimating Inputs of Binaural Neurons Through the Temporal Analysis of Spike Trains.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Auditory Model-Based Sound Direction Estimation With Bilateral Cochlear Implants.Trends in hearing · 2015Review
- Limitations on Monaural and Binaural Temporal Processing in Bilateral Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints.Trends in hearingReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bilateral cochlear implants (CIs) provide improvements in sound localization and speech perception in noise over unilateral CIs. However, the benefits arise mainly from the perception of interaural level differences, while bilateral CI listeners' sensitivity to interaural time difference (ITD) is poorer than normal. To help understand this limitation, a set of ITD-sensitive neural models was developed to study binaural responses to electric stimulation. Our working hypothesis was that central auditory processing is normal with bilateral CIs so that the abnormality in the response to electric stimulation at the level of the auditory nerve fibers (ANFs) is the source of the limited ITD sensitivity. A descriptive model of ANF response to both acoustic and electric stimulation was implemented and used to drive a simplified biophysical model of neurons in the medial superior olive (MSO). The model's ITD sensitivity was found to depend strongly on the specific configurations of membrane and synaptic parameters for different stimulation rates. Specifically, stronger excitatory synaptic inputs and faster membrane responses were required for the model neurons to be ITD-sensitive at high stimulation rates, whereas weaker excitatory synaptic input and slower membrane responses were necessary at low stimulation rates, for both electric and acoustic stimulation. This finding raises the possibility of frequency-dependent differences in neural mechanisms of binaural processing; limitations in ITD sensitivity with bilateral CIs may be due to a mismatch between stimulation rate and cell parameters in ITD-sensitive neurons.
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