Evidence map›Paper›PMID 25348541›Full record

ArticleAntimicrobial agents and chemotherapy2015

Contaminated handwashing sinks as the source of a clonal outbreak of KPC-2-producing Klebsiella oxytoca on a hematology ward.

Eva Leitner, Gernot Zarfel, Josefa Luxner, Kathrin Herzog, Shiva Pekard-Amenitsch, Martin Hoenigl, Thomas Valentin, Gebhard Feierl, Andrea J Grisold, Christoph Högenauer and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
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  7. Insights into the Metabolic Adaptations of a Carbapenem-ResistantInternational journal of molecular sciences · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Eva LeitnerInstitute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Gernot ZarfelInstitute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Josefa LuxnerInstitute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Kathrin HerzogDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Shiva Pekard-AmenitschAustrian Agency for Health and Food Safety, Institute of Medical Microbiology and Hygiene, Graz, Austria.
Martin HoeniglSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thomas ValentinSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Gebhard FeierlInstitute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Andrea J GrisoldInstitute of Hygiene Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Christoph HögenauerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Heinz SillDivision of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Robert KrauseSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Ines Zollner-SchwetzSection of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria ines.schwetz@medunigraz.at.
Medical University of Graz · ATAustrian Agency for Health and Food Safety · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated sinks as possible sources of a prolonged Klebsiella pneumonia carbapenemase (KPC)-producing Klebsiella oxytoca outbreak. Seven carbapenem-resistant K. oxytoca isolates were identified in sink drains in 4 patient rooms and in the medication room. Investigations for resistance genes and genetic relatedness of patient and environmental isolates revealed that all the isolates harbored the blaKPC-2 and blaTEM-1 genes and were genetically indistinguishable. We describe here a clonal outbreak caused by KPC-2-producing K. oxytoca, and handwashing sinks were a possible reservoir.

Indexed as

Equipment ContaminationKlebsiella oxytocabeta-LactamasesCross InfectionDisease OutbreaksHand DisinfectionHematologyHospital DepartmentsHumansKlebsiella Infectionsbeta-lactamase KPC-2beta-Lactamases

Identifiers

PMID25348541
PMCPMC4291428
OpenAlexW2154740365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.