Evidence map›Paper›PMID 25348521›Full record

ArticleAntimicrobial agents and chemotherapy2015

Synergistic interactions of vancomycin with different antibiotics against Escherichia coli: trimethoprim and nitrofurantoin display strong synergies with vancomycin against wild-type E. coli.

Alice Zhou, Tina Manzhu Kang, Jessica Yuan, Casey Beppler, Caroline Nguyen, Zhiyuan Mao, Minh Quan Nguyen, Pamela Yeh, Jeffrey H Miller

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 76 citations in OpenAlex.

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  9. Review
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  11. Inhibition of MurA Enzyme fromAntibiotics (Basel, Switzerland) · 2021
    Article
  12. Article
  13. Review
  14. Review
  15. Antimicrobial agents and chemotherapy · 2021
    Article
  16. Journal of medical microbiology · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alice ZhouDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Tina Manzhu KangDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jessica YuanDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Casey BepplerDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Caroline NguyenDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Zhiyuan MaoDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Minh Quan NguyenDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Pamela YehDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, California, USA pamelayeh@ucla.edu jhmiller@microbio.ucla.edu.
Jeffrey H MillerDepartment of Microbiology, Immunology, and Molecular Genetics, the Molecular Biology Institute, and the David Geffen School of Medicine, University of California, Los Angeles, California, USA pamelayeh@ucla.edu jhmiller@microbio.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

Gram-negative bacteria are normally resistant to the antibiotic vancomycin (VAN), which cannot significantly penetrate the outer membrane. We used Escherichia coli mutants that are partially sensitive to VAN to study synergies between VAN and 10 other antibiotics representing six different functional categories. We detected strong synergies with VAN and nitrofurantoin (NTR) and with VAN and trimethoprim (TMP) and moderate synergies with other drugs, such as aminoglycosides. These synergies are powerful enough to show the activity of VAN against wild-type E. coli at concentrations of VAN as low as 6.25 μg/ml. This suggests that a very small percentage of exogenous VAN does enter E. coli but normally has insignificant effects on growth inhibition or cell killing. We used the results of pairwise interactions with VAN and the other 10 antibiotics tested to place VAN into a functional category of its own, as previously defined by Yeh et al. (P. Yeh, A. I. Tschumi, and R. Kishony, Nat Genet 28:489-494, 2006, http://dx.doi.org/10.1038/ng1755).

Indexed as

Anti-Bacterial AgentsCarrier ProteinsDose-Response Relationship, DrugDrug SynergismDrug Therapy, CombinationEscherichia coliEscherichia coli ProteinsMutationNitrofurantoinPeptidylprolyl IsomeraseTrimethoprimVancomycinAnti-Bacterial AgentsCarrier ProteinsEscherichia coli ProteinsNitrofurantoinPeptidylprolyl IsomeraseSurA protein, E coliTrimethoprimVancomycin

Identifiers

PMID25348521
PMCPMC4291362
OpenAlexW2159641002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.