Evidence map›Paper›PMID 25348408›Full record

ArticleNucleic acids research2015

CATH: comprehensive structural and functional annotations for genome sequences.

Ian Sillitoe, Tony E Lewis, Alison Cuff, Sayoni Das, Paul Ashford, Natalie L Dawson, Nicholas Furnham, Roman A Laskowski, David Lee, Jonathan G Lees and 4 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

223 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Evidence for vitellogenin DNA-binding in honey bees.Protein science : a publication of the Protein Society · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Mutual annotation-based prediction of protein domain functions with Domain2GO.Protein science : a publication of the Protein Society · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Genome-Wide Analysis ofInternational journal of molecular sciences · 2023
    Article

163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ian SillitoeInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.
Tony E LewisInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Alison CuffInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Sayoni DasInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Paul AshfordInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Natalie L DawsonInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Nicholas FurnhamLondon School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Roman A LaskowskiEuropean Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
David LeeInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Jonathan G LeesInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Sonja LehtinenInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
Romain A StuderEuropean Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
Janet ThorntonEuropean Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
Christine A OrengoInstitute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/K020013/1Cancer Research UK 16567Medical Research Council MR/K020420/1Wellcome Trust 081989/Z/07/Z
6 · The paper itself

Abstract

The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

Indexed as

Databases, ProteinMolecular Sequence AnnotationProtein Structure, TertiaryGenomicsInternetProteinsProteins

Identifiers

PMID25348408
PMCPMC4384018

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.