ArticleBrain structure & function2016
Repeated administration of a synthetic cannabinoid receptor agonist differentially affects cortical and accumbal neuronal morphology in adolescent and adult rats.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Age-related differences in the impact of cannabis use on the brain and cognition: a systematic review.European archives of psychiatry and clinical neuroscience · 2019Pooled it
- Are adolescents more vulnerable to the harmful effects of cannabis than adults? A placebo-controlled study in human males.Translational psychiatry · 2016Trial
- Age-Related Effects of Cannabis and Cannabinoids on Brain and Behavior.Cannabis and cannabinoid research · 2026Review
- Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms.Cannabis and cannabinoid research · 2023Review
- Psychotropic drug abuse in pregnancy and its impact on child neurodevelopment: A review.World journal of clinical pediatrics · 2022Review
- The stoned age: Sex differences in the effects of adolescent cannabinoid exposure on prefrontal cortex structure and function in animal models.International review of neurobiology · 2022Review
- Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment.Biomolecules · 2021Review
- The why behind the high: determinants of neurocognition during acute cannabis exposure.Nature reviews. Neuroscience · 2021Review
- Chronic cannabinoid exposure produces tolerance to the dopamine releasing effects of WIN 55,212-2 and heroin in adult male rats.Neuropharmacology · 2021Article
- The Neuroscience of Drug Reward and Addiction.Physiological reviews · 2019Review
- Associations between adolescent cannabis use and brain structure in psychosis.Psychiatry research. Neuroimaging · 2018Article
- mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward.Frontiers in neuroscience · 2018Article
- Selective effects of Δ9-tetrahydrocannabinol on medium spiny neurons in the striatum.PloS one · 2018Article
- ΔCannabis and cannabinoid research · 2017Article
- Estradiol impacts the endocannabinoid system in female rats to influence behavioral and structural responses to cocaine.Neuropharmacology · 2016Article
- Δ(9)-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids in mice and rats.Psychopharmacology · 2016Article
- Emergence of sex differences in the development of substance use and abuse during adolescence.Pharmacology & therapeutics · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies demonstrate a differential trajectory for cannabinoid receptor expression in cortical and sub-cortical brain areas across postnatal development. In the present study, we sought to investigate whether chronic systemic exposure to a synthetic cannabinoid receptor agonist causes morphological changes in the structure of dendrites and dendritic spines in adolescent and adult pyramidal neurons in the medial prefrontal cortex (mPFC) and medium spiny neurons (MSN) in the nucleus accumbens (Acb). Following systemic administration of WIN 55,212-2 in adolescent (PN 37-40) and adult (P55-60) male rats, the neuronal architecture of pyramidal neurons and MSN was assessed using Golgi-Cox staining. While no structural changes were observed in WIN 55,212-2-treated adolescent subjects compared to control, exposure to WIN 55,212-2 significantly increased dendritic length, spine density and the number of dendritic branches in pyramidal neurons in the mPFC of adult subjects when compared to control and adolescent subjects. In the Acb, WIN 55,212-2 exposure significantly decreased dendritic length and number of branches in adult rat subjects while no changes were observed in the adolescent groups. In contrast, spine density was significantly decreased in both the adult and adolescent groups in the Acb. To determine whether regional developmental morphological changes translated into behavioral differences, WIN 55,212-2-induced aversion was evaluated in both groups using a conditioned place preference paradigm. In adult rats, WIN 55,212-2 administration readily induced conditioned place aversion as previously described. In contrast, adolescent rats did not exhibit aversion following WIN 55,212-2 exposure in the behavioral paradigm. The present results show that synthetic cannabinoid administration differentially impacts cortical and sub-cortical neuronal morphology in adult compared to adolescent subjects. Such differences may underlie the disparate development effects of cannabinoids on behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.