ArticleSleep2015
Abnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- NoSAS score and the 5-year risk of incident cerebrovascular disease: a retrospective cohort study.Frontiers in medicine · 2026Article
- Relationships between apolipoprotein E and insulin resistance in patients with obstructive sleep apnoea: a large-scale cross-sectional study.Nutrition & metabolism · 2024Article
- Genetic variations of low-density lipoprotein cholesterol on metabolic disorders in obstructive sleep apnea.Nutrition & metabolism · 2024Article
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Article
- Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
- The Automatic Algorithm of the Auto-CPAP Device as a Tool for the Assessment of the Treatment Efficacy of CPAP in Patients with Moderate and Severe Obstructive Sleep Apnea Syndrome.Life (Basel, Switzerland) · 2022Article
- Evaluation of the Ocular Surface and Meibomian Gland in Obstructive Sleep Apnea Hypopnea Syndrome.Frontiers in medicine · 2022Article
- Correlation of Dyslipidemia and Inflammation With Obstructive Sleep Apnea Severity.Frontiers in pharmacology · 2022Article
- The impact of sleep apnea syndrome on the altered lipid metabolism and the redox balance.Lipids in health and disease · 2021Article
- Body Mass Index Reduction and Selected Cardiometabolic Risk Factors in Obstructive Sleep Apnea: Meta-Analysis.Journal of clinical medicine · 2021Review
- Influence of multiple apolipoprotein A-I and B genetic variations on insulin resistance and metabolic syndrome in obstructive sleep apnea.Nutrition & metabolism · 2020Article
- The association between obstructive sleep apnea syndrome and metabolic syndrome: a confirmatory factor analysis.Sleep & breathing = Schlaf & Atmung · 2019Article
- Relationships between cardiometabolic disorders and obstructive sleep apnea: Implications for cardiovascular disease risk.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease.Frontiers in endocrinology · 2018Review
- Prevalence and Predictors of Atherogenic Serum Lipoprotein Dyslipidemia in Women with Obstructive Sleep Apnea.Scientific reports · 2017Article
- Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea.American journal of physiology. Heart and circulatory physiology · 2015Review
- Usefulness of fetuin-A to predict risk for cardiovascular disease among patients with obstructive sleep apnea.The American journal of cardiology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivePrevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia in these individuals. Insulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear. The study's aim was to define the relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance.
designCross-sectional study. OSA severity was defined by the apnea-hypopnea index (AHI) during polysomnography. Hypoxia measures were expressed as minimum and mean oxygen saturation, and the oxygen desaturation index. Insulin resistance was quantified by determining steady-state plasma glucose (SSPG) concentrations during the insulin suppression test. Fasting plasma lipid/lipoprotein evaluation was performed by vertical auto profile methodology.
settingAcademic medical center.
participants107 nondiabetic, overweight/obese adults. MEASUREMENTS AND
resultsLipoprotein particles did not correlate with AHI or any hypoxia measures, nor were there differences noted by categories of OSA severity. By contrast, even after adjustment for age, sex, and BMI, SSPG was positively correlated with triglycerides (r = 0.30, P < 0.01), very low density lipoprotein (VLDL) and its subclasses (VLDL1+2) (r = 0.21-0.23, P < 0.05), and low density lipoprotein subclass 4 (LDL4) (r = 0.30, P < 0.01). SSPG was negatively correlated with high density lipoprotein (HDL) (r = -0.38, P < 0.001) and its subclasses (HDL2 and HDL3) (r = -0.32, -0.43, P < 0.01), and apolipoprotein A1 (r = -0.33, P < 0.01). Linear trends of these lipoprotein concentrations across SSPG tertiles were also significant.
conclusionsPro-atherogenic lipoprotein abnormalities in obstructive sleep apnea (OSA) are related to insulin resistance, but not to OSA severity or degree of hypoxia. Insulin resistance may represent the link between OSA-related dyslipidemia and increased cardiovascular disease risk.
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Registered trials
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