ArticlePhysiological reports2014
Eccentric contractions disrupt FKBP12 content in mouse skeletal muscle.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
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- Beyond the first bout: Adaptations to repeated injuries across physiological and pathological conditions.Physiological reports · 2026Review
- Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025Review
- Neuromuscular mechanisms of weakness in a mouse model of chronic alcoholic myopathy.Alcoholism, clinical and experimental research · 2022Article
- The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles.International journal of molecular sciences · 2021Review
- Impact of estrogen deficiency on diaphragm and leg muscle contractile function in female mdx mice.PloS one · 2021Article
- Muscle Strength and Power: Primary Outcome Measures to Assess Cold Water Immersion Efficacy After Exercise With a Strong Strength or Power Component.Frontiers in sports and active living · 2021Article
- Contraction-Induced Loss of Plasmalemmal Electrophysiological Function Is Dependent on the Dystrophin Glycoprotein Complex.Frontiers in physiology · 2021Article
- Oestradiol affects skeletal muscle mass, strength and satellite cells following repeated injuries.Experimental physiology · 2020Article
- Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice.The Journal of clinical investigation · 2020Article
- Plasmalemma Function Is Rapidly Restored in Mdx Muscle after Eccentric Contractions.Medicine and science in sports and exercise · 2020Article
- Estrogen Regulates the Satellite Cell Compartment in Females.Cell reports · 2019Article
- Downhill exercise alters immunoproteasome content in mouse skeletal muscle.Cell stress & chaperones · 2018Article
- Regeneration of Skeletal Muscle After Eccentric Injury.Journal of sport rehabilitation · 2017Review
- Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Utility of 17-(allylamino)-17-demethoxygeldanamycin treatment for skeletal muscle injury.Cell stress & chaperones · 2016Article
- Denervation-Induced Activation of the Ubiquitin-Proteasome System Reduces Skeletal Muscle Quantity Not Quality.PloS one · 2016Article
- Functional recovery from eccentric injury is maintained in sarcopenic mouse muscle.JCSM rapid communicationsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strength deficits associated with eccentric contraction-induced muscle injury stem, in part, from impaired voltage-gated sarcoplasmic reticulum (SR) Ca(2+) release. FKBP12 is a 12-kD immunophilin known to bind to the SR Ca(2+) release channel (ryanodine receptor, RyR1) and plays an important role in excitation-contraction coupling. To assess the effects of eccentric contractions on FKBP12 content, we measured anterior crural muscle (tibialis anterior [TA], extensor digitorum longus [EDL], extensor hallucis longus muscles) strength and FKBP12 content in pellet and supernatant fractions after centrifugation via immunoblotting from mice before and after a single bout of either 150 eccentric or concentric contractions. There were no changes in peak isometric torque or FKBP12 content in TA muscles after concentric contractions. However, FKBP12 content was reduced in the pelleted fraction immediately after eccentric contractions, and increased in the soluble protein fraction 3 day after injury induction. FKBP12 content was correlated (P = 0.025; R(2) = 0.38) to strength deficits immediately after injury induction. In summary, eccentric contraction-induced muscle injury is associated with significant alterations in FKBP12 content after injury, and is correlated with changes in peak isometric torque.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.