ArticlePhysiological reports2014
Enhanced muscle pump during mild dynamic leg exercise inhibits sympathetic vasomotor outflow.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
- Hypohydration Increases Heart Rate Despite Preserved Hemodynamic Compensation During Blood Flow Restricted Exercise.Scandinavian journal of medicine & science in sports · 2026Article
- Repeatability of heart-rate variability and baroreflex sensitivity as metrics of cardiac autonomic function during exercise in young females and males.European journal of applied physiology · 2026Article
- Effects of local vibration stimulation on muscle recovery and hypertrophy.Journal of physical therapy science · 2024Article
- Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals.The journal of physiological sciences : JPS · 2024Article
- Response to Letter to Editor - Comments on: Sympathetic vasomotor outflow during low-intensity leg cycling in healthy older males.Experimental physiology · 2023Article
- Differential contributions of cardiac, coronary and pulmonary artery vagal mechanoreceptors to reflex control of the circulation.The Journal of physiology · 2022Review
- Influence of cardiac output response to the onset of exercise on cerebral blood flow.European journal of applied physiology · 2022Article
- Temporal Skin Temperature as an Indicator of Cardiorespiratory Fitness Assessed with Selected Methods.Biology · 2022Article
- Cerebral blood velocity and arterial pressure at the onset of exercise: potential influence of the cardiopulmonary baroreflex.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Intra-rater reliability of leg blood flow during dynamic exercise using Doppler ultrasound.Physiological reports · 2021Article
- High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men.European journal of applied physiology · 2021Article
- The exercise pressor reflex and chemoreflex interaction: cardiovascular implications for the exercising human.The Journal of physiology · 2020Article
- Training heart failure patients with reduced ejection fraction attenuates muscle sympathetic nerve activation during mild dynamic exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Effects of dynamic arm and leg exercise on muscle sympathetic nerve activity and vascular conductance in the inactive leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Muscle sympathetic nerve activity during exercise.The journal of physiological sciences : JPS · 2019Review
- High-intensity muscle metaboreflex activation attenuates cardiopulmonary baroreflex-mediated inhibition of muscle sympathetic nerve activity.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Muscle sympathetic nerve responses to passive and active one-legged cycling: insights into the contributions of central command.American journal of physiology. Heart and circulatory physiology · 2018Article
- Exercise intensity modulates brachial artery retrograde blood flow and shear rate during leg cycling in hypoxia.Physiological reports · 2015Article
- Sympathetic vasomotor outflow and blood pressure increase during exercise with expiratory resistance.Physiological reports · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle sympathetic nerve activity (MSNA) is not increased during leg cycling at light and mild intensities, despite activation of central command and the exercise pressor reflex. We determined whether increasing central blood volume and loading the cardiopulmonary baroreceptors modulate sympathetic vasomotor outflow during leg cycling. To this end, we changed the pedaling frequency to enhance skeletal muscle pump. Subjects performed two leg cycle exercises at differential pedal rates of 60 and 80 rpm (60EX and 80EX trials) for two conditions (with and without MSNA measurement). In each trial, subjects completed leg cycling with a differential workload to maintain constant oxygen consumption (VO2). MSNA was recorded via microneurography at the right median nerve of the elbow. Without MSNA measurement, thoracic impedance, stroke volume (SV), and cardiac output (CO) were measured non-invasively using impedance cardiography. Heart rate and VO2 during exercise did not differ between the 60EX and 80EX trials. Changes in thoracic impedance, SV, and CO during the 80EX trial were greater than during the 60EX trial. MSNA during the 60EX trial was unchanged compared with that at rest (25.8 ± 3.1 [rest] to 28.3 ± 3.4 [exercise] bursts/min), whereas a significant decrease in MSNA was observed during the 80EX trial (25.8 ± 2.8 [rest] to 19.7 ± 2.0 [exercise] bursts/min). These results suggest that a muscle pump-induced increase in central blood volume, and thereby loading of cardiopulmonary baroreceptors, could inhibit sympathetic vasomotor outflow during mild dynamic leg exercise, despite activation of central command and the exercise pressor reflex.
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