ArticlePloS one2014
MSH1-induced non-genetic variation provides a source of phenotypic diversity in Sorghum bicolor.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Expansion of the MutS gene family in plants.The Plant cell · 2025Article
- Expansion of the MutS Gene Family in Plants.bioRxiv : the preprint server for biology · 2024Article
- Identification, cloning and characterization of AcMSH1 from Onion (Allium cepa L.).Molecular biology reports · 2023Article
- OMICs, Epigenetics, and Genome Editing Techniques for Food and Nutritional Security.Plants (Basel, Switzerland) · 2021Review
- Implementation of Epigenetic Variation in Sorghum Selection and Implications for Crop Resilience Breeding.Frontiers in plant science · 2021Article
- Mechanisms of Genome Maintenance in Plants: Playing It Safe With Breaks and Bumps.Frontiers in genetics · 2021Review
- Epigenetics and epigenomics: underlying mechanisms, relevance, and implications in crop improvement.Functional & integrative genomics · 2020Review
- Organellar protein multi-functionality and phenotypic plasticity in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Many Facets of Dynamic Plasticity in Plants.Cold Spring Harbor perspectives in biology · 2019Review
- Genome-wide association mapping in a diverse spring barley collection reveals the presence of QTL hotspots and candidate genes for root and shoot architecture traits at seedling stage.BMC plant biology · 2019Article
- Mitotypes Based on Structural Variation of Mitochondrial Genomes Imply Relationships With Morphological Phenotypes and Cytoplasmic Male Sterility in Peppers.Frontiers in plant science · 2019Article
- An epigenetic breeding system in soybean for increased yield and stability.Plant biotechnology journal · 2018Article
- Article
- Recent research on the mechanism of heterosis is important for crop and vegetable breeding systems.Breeding science · 2018Review
- Stress-responsive pathways and small RNA changes distinguish variable developmental phenotypes caused by MSH1 loss.BMC plant biology · 2017Article
- Novel nuclear-cytoplasmic interaction in wheat (Triticum aestivum) induces vigorous plants.Functional & integrative genomics · 2016Article
- MutS HOMOLOG1-derived epigenetic breeding potential in tomato.Plant physiology · 2015Article
- Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth.Nature communications · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MutS Homolog 1 (MSH1) encodes a plant-specific protein that functions in mitochondria and chloroplasts. We showed previously that disruption or suppression of the MSH1 gene results in a process of developmental reprogramming that is heritable and non-genetic in subsequent generations. In Arabidopsis, this developmental reprogramming process is accompanied by striking changes in gene expression of organellar and stress response genes. This developmentally reprogrammed state, when used in crossing, results in a range of variation for plant growth potential. Here we investigate the implications of MSH1 modulation in a crop species. We found that MSH1-mediated phenotypic variation in Sorghum bicolor is heritable and potentially valuable for crop breeding. We observed phenotypic variation for grain yield, plant height, flowering time, panicle architecture, and above-ground biomass. Focusing on grain yield and plant height, we found some lines that appeared to respond to selection. Based on amenability of this system to implementation in a range of crops, and the scope of phenotypic variation that is derived, our results suggest that MSH1 suppression provides a novel approach for breeding in crops.
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