ArticlePlastic and reconstructive surgery2014
Electron microscopic and proteomic comparison of terminal branches of the trigeminal nerve in patients with and without migraine headaches.
Article in Plastic and reconstructive surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review.Frontiers in pharmacology · 2024Pooled it
- Cortical network dysfunction in migraine: linking genes, metabolism and clinical disability.The journal of headache and pain · 2025Article
- The serum proteomic profile in patients with migraine.Frontiers in molecular neuroscience · 2025Article
- Comprehensive Criteria for Differential Diagnosis and a Surgical Management Algorithm for Occipital Neuralgia and Migraine Headaches.JPRAS open · 2024Article
- Introduction to VSI: Migraine surgery in JPRAS open.JPRAS open · 2024Article
- Secondary Trigger Point Deactivation Surgery for Nerve Compression Headaches: A Scoping Review.Plastic and reconstructive surgery. Global open · 2024Article
- Neurovascular Compression-Induced Intracranial Allodynia May Be the True Nature of Migraine Headache: an Interpretative Review.Current pain and headache reports · 2023Review
- Bottom-Up Proteomics: Advancements in Sample Preparation.International journal of molecular sciences · 2023Review
- Targeting N-type calcium channels in young-onset of some neurological diseases.Frontiers in cell and developmental biology · 2022Review
- Alterations in brain structure associated with trigeminal nerve anatomy in episodic migraine.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Network-guided search for genetic heterogeneity between gene pairs.Bioinformatics (Oxford, England) · 2021Article
- Peripheral Occipital Nerve Decompression Surgery in Migraine Headache.Plastic and reconstructive surgery. Global open · 2020Article
- Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.The journal of headache and pain · 2020Article
- Migraine Surgery.Plastic and reconstructive surgery. Global open · 2019Review
- Entrapment Neuropathy: A Concept for Pathogenesis and Treatment of Headaches-A Narrative Review.Clinical medicine insights. Ear, nose and throat · 2019Review
- Ion channelopathies and migraine pathogenesis.Molecular genetics and genomics : MGG · 2017Review
- Efficacy of (Pain reports · 2016Article
- Decompression-Avulsion of the Auriculotemporal Nerve for Treatment of Migraines and Chronic Headaches.Plastic and reconstructive surgery. Global open · 2016Article
- Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.Human genetics · 2016Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe purpose of this study was to compare the ultrastructural appearance and protein expression of the zygomaticotemporal branch of the trigeminal nerve in patients with and without migraine headaches.
methodsAfter confirmation of migraine headache diagnosis on 15 patients, a 5-mm segment of the zygomaticotemporal branch of the trigeminal nerve that is routinely removed during migraine surgery was compared to similarly sized nerve segments obtained from 15 control patients without a history of migraine headaches, who underwent an endoscopic forehead lift where this nerve is routinely transected. The segments were snap-frozen at -80°C for the downstream proteomics analysis. In addition, the cytoarchitectural differences of the nerve segments obtained from the 15 migraine and 15 control subjects were examined in detail under the electron microscope.
resultsAnalysis of liquid chromatography/tandem mass spectrometry data sets identified differentially expressed proteins and networks composed of highly connected molecular modules (p=10 and p=10) in patients with migraine headaches. The nerves from patients with migraine headaches had a linear organization, disrupted myelin sheaths and target axons, and discontinuous neurofilaments that were poorly registered with the discontinuous myelin sheaths, suggesting axonal abnormality.
conclusionsThis study offers electron microscopic and proteomic evidence of axonal abnormality and deregulation of the myelination process in patients with migraine headaches compared with controls, offering the first objective evidence to support the role of peripheral mechanisms in the migraine headache cascade and an explanation as to why the surgical treatment of migraine headaches is efficacious.
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