Trial reportThe Journal of clinical investigation2014
Hair keratin mutations in tooth enamel increase dental decay risk.
Trial report in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Keratin-based protection of enamel against acid-erosion.Frontiers in dental medicine · 2026Article
- p63 co-opts the skin Krt8-to-Krt5 transition for enamel organ development.bioRxiv : the preprint server for biology · 2025Article
- Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Article
- MEMO1 Is Required for Ameloblast Maturation and Functional Enamel Formation.Journal of dental research · 2023Article
- Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response during Wound Repair.The Journal of investigative dermatology · 2023Article
- Investigation on Enamel and Dentine of Tooth through 1D Photonic Structure to Identify the Caries in Human Teeth.Bioengineering (Basel, Switzerland) · 2022Article
- Paleoproteomics.Chemical reviews · 2022Review
- Elucidating the role of keratin 75 in enamel using Krt75Frontiers in physiology · 2022Article
- Real-Time Monitoring and Quantitative Evaluation of Resin In-Filtrant Repairing Enamel White Spot Lesions Based on Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2021Article
- Dental Caries in Adults with Atopic Dermatitis: A Nationwide Cross-Sectional Study in Korea.Annals of dermatology · 2021Article
- Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.Biomolecules · 2020Article
- ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.Autophagy · 2020Article
- Trafficking and secretion of keratin 75 by ameloblastsThe Journal of biological chemistry · 2019Article
- Enamel Anomalies in a Pachyonychia Congenita Patient with a Mutation in KRT16.The Journal of investigative dermatology · 2019Article
- Pleiotropic function of DLX3 in amelogenesis: from regulating pH and keratin expression to controlling enamel rod decussation.Connective tissue research · 2018Article
- Msx2 Prevents Stratified Squamous Epithelium Formation in the Enamel Organ.Journal of dental research · 2018Article
- Homeobox transcription factor DLX4 is not necessary for skin development and homeostasis.Experimental dermatology · 2018Article
- Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.PLoS genetics · 2018Article
- DLX3-Dependent Regulation of Ion Transporters and Carbonic Anhydrases is Crucial for Enamel Mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Tooth enamel is the hardest substance in the human body and has a unique combination of hardness and fracture toughness that protects teeth from dental caries, the most common chronic disease worldwide. In addition to a high mineral content, tooth enamel comprises organic material that is important for mechanical performance and influences the initiation and progression of caries; however, the protein composition of tooth enamel has not been fully characterized. Here, we determined that epithelial hair keratins, which are crucial for maintaining the integrity of the sheaths that support the hair shaft, are expressed in the enamel organ and are essential organic components of mature enamel. Using genetic and intraoral examination data from 386 children and 706 adults, we found that individuals harboring known hair disorder-associated polymorphisms in the gene encoding keratin 75 (KRT75), KRT75(A161T) and KRT75(E337K), are prone to increased dental caries. Analysis of teeth from individuals carrying the KRT75(A161T) variant revealed an altered enamel structure and a marked reduction of enamel hardness, suggesting that a functional keratin network is required for the mechanical stability of tooth enamel. Taken together, our results identify a genetic locus that influences enamel structure and establish a connection between hair disorders and susceptibility to dental caries.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.