Evidence map›Paper›PMID 25347455›Full record

ReviewMolecules (Basel, Switzerland)2014

Endocannabinoids, related compounds and their metabolic routes.

Filomena Fezza, Monica Bari, Rita Florio, Emanuela Talamonti, Monica Feole, Mauro Maccarrone

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Review
  9. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
  10. Article
  11. Review
  12. Dietary Manganese Modulates Microbiota and Intestinal N-Acylethanolamines in a Sex-Specific Manner in Mice With Diet-Induced Obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  13. The Role of the Endocannabinoid System in Human Gametogenesis.International journal of molecular sciences · 2025
    Review
  14. Review
  15. Role of the Endocannabinoid System in Fibromyalgia.Current issues in molecular biology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Filomena FezzaDepartment of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy. filomena.fezza@uniroma2.it.
Monica BariDepartment of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy. bari@med.uniroma2.it.
Rita FlorioDepartment of Movement, Human and Health Sciences, Foro Italico University of Rome, 00128 Rome, Italy. rit.flo@libero.it.
Emanuela TalamontiEndocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli (NA), Italy. emanuelatalamonti.86@libero.it.
Monica FeoleDepartment of Experimental Medicine & Surgery, Tor Vergata University of Rome, 00133 Rome, Italy. monica.feole@hotmail.it.
Mauro MaccarroneEuropean Center for Brain Research/IRCCS Santa Lucia Foundation, 00143 Rome, Italy. m.maccarrone@unicampus.it.
University of Rome Tor Vergata · ITEuropean Brain Research Institute · ITForo Italico University of Rome · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the pharmacological effects of the Δ9-tetrahydrocannabinol. These bioactive lipids belong mainly to two classes of compounds: N-acylethanolamines and acylesters, being N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), respectively, their main representatives. During the last twenty years, an ever growing number of fatty acid derivatives (endocannabinoids and endocannabinoid-like compounds) have been discovered and their activities biological is the subject of intense investigations. Here, the most recent advances, from a therapeutic point of view, on endocannabinoids, related compounds, and their metabolic routes will be reviewed.

Indexed as

AnimalsArachidonic AcidsDronabinolEndocannabinoidsEthanolaminesFatty AcidsGlyceridesHumansPolyunsaturated AlkamidesanandamideArachidonic AcidsDronabinolEndocannabinoidsEthanolaminesFatty AcidsGlyceridesglyceryl 2-arachidonateN-acylethanolaminesPolyunsaturated Alkamides

Identifiers

PMID25347455
PMCPMC6271436
OpenAlexW2076228635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.