Evidence map›Paper›PMID 25347344›Full record

ArticleOncotarget2014

Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.

Malak S Abedalthagafi, Parker H Merrill, Wenya Linda Bi, Robert T Jones, Marc L Listewnik, Shakti H Ramkissoon, Aaron R Thorner, Ian F Dunn, Rameen Beroukhim, Brian M Alexander and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Angiomatous meningioma with bizarre nuclei: A case report.Molecular and clinical oncology · 2023
    Article
  8. Radiotherapy and radiosurgery for meningiomas.Neuro-oncology advances · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Infarction with associated pseudosarcomatous changes mimics anaplasia in otherwise grade I meningiomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020
    Article
  14. Molecular characteristics of meningiomas.Journal of pathology and translational medicine · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Malak S AbedalthagafiDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Parker H MerrillDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Wenya Linda BiDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Robert T JonesDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc L ListewnikClinical Cytogenetics Laboratory, Center for Advanced Molecular Diagnostics, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shakti H RamkissoonDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aaron R ThornerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA.
Ian F DunnDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rameen BeroukhimDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Brian M AlexanderDepartment of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Priscilla K BrastianosDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. Department of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joshua M FrancisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Rebecca D FolkerthDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Keith L LigonDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Paul Van HummelenDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA.
Azra H LigonClinical Cytogenetics Laboratory, Center for Advanced Molecular Diagnostics, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sandro SantagataDepartment of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USDana-Farber Cancer Institute · USBroad Institute · USMassachusetts General Hospital · US

Funding

ALK signaling in CNS development, ischemic brain injury and gliomagenesisK08NS087118 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAMKISSOON, SHAKTI H · 2014 to 2015
$387k
NINDS NIH HHS K08 NS087118
6 · The paper itself

Abstract

Meningiomas are a diverse group of tumors with a broad spectrum of histologic features. There are over 12 variants of meningioma, whose genetic features are just beginning to be described. Angiomatous meningioma is a World Health Organization (WHO) meningioma variant with a predominance of blood vessels. They are uncommon and confirming the histopathologic classification can be challenging. Given a lack of biomarkers that define the angiomatous subtype and limited understanding of the genetic changes underlying its tumorigenesis, we compared the genomic characteristics of angiomatous meningioma to more common meningioma subtypes. While typical grade I meningiomas demonstrate monosomy of chromosome 22 or lack copy number aberrations, 13 of 14 cases of angiomatous meningioma demonstrated a distinct copy number profile--polysomies of at least one chromosome, but often of many, especially in chromosomes 5, 13, and 20. WHO grade II atypical meningiomas with angiomatous features have both polysomies and genetic aberrations characteristic of other atypical meningiomas. Sequencing of over 560 cancer-relevant genes in 16 cases of angiomatous meningioma showed that these tumors lack common mutations found in other variants of meningioma. Our study demonstrates that angiomatous meningiomas have distinct genomic features that may be clinically useful for their diagnosis.

Indexed as

Chromosome AberrationsTranscriptomeBiomarkers, TumorChromosomes, Human, Pair 5Comparative Genomic HybridizationDNA Copy Number VariationsExonsHigh-Throughput Nucleotide SequencingHumansMeningeal NeoplasmsMeningiomaMutationNeoplasm GradingBiomarkers, Tumor

Identifiers

PMID25347344
PMCPMC4279396
OpenAlexW2171571619

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.