ArticleInternational journal of molecular sciences2014
Genetic variations rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Pathologic collision of urinary bladder urothelial carcinoma with small cell carcinoma: a case report.Diagnostic pathology · 2023Article
- Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.Oncology reviews · 2023Article
- Genetic susceptibility of bladder cancer in the Lebanese population.BMC medical genomics · 2022Review
- The Rare Variant rs35356162 inFrontiers in oncology · 2020Article
- Correlation of IL-31 gene polymorphisms with susceptibility and clinical recurrence of bladder cancer.Familial cancer · 2018Article
- Article
- Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in bladder cancer.International journal of clinical and experimental pathology · 2017Article
- Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in Gansu province of China.Oncotarget · 2016Article
- The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants.International journal of environmental research and public health · 2016Review
- Association of gastrointestinal gland cancer susceptibility loci with esophageal carcinoma among the Chinese Han population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Rs401681 polymorphism in TERT-CLPTM1L was associated with bladder cancer risk: A meta-analysis.Iranian journal of basic medical sciences · 2015Article
- Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis.OncoTargets and therapy · 2015Article
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14 authors.
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Abstract
Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09-0.81; p=0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10-2.91; p=0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study.
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