ArticlePloS one2014
Effects of moderate aerobic exercise training on hemorheological and laboratory parameters in ischemic heart disease patients.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease.Frontiers in cardiovascular medicine · 2022Pooled it
- Cardiac Rehabilitation with Targeted Intensity Improves Cardiopulmonary Functions Accompanying with Reduced Copeptin Level in Patients with Coronary Artery Disease.Journal of cardiovascular translational research · 2021Trial
- Twelve Weeks of Combined Resistance and Aerobic Exercise Improves Cardiometabolic Biomarkers and Enhances Red Blood Cell Hemorheological Function in Obese Older Men: A Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Effects and mechanism of moderate aerobic exercise on impaired fasting glucose improvement.Lipids in health and disease · 2015Trial
- Evidence-Based Laboratory Medicine for Cardiovascular Disease Management in Mental Healthcare: A Literature Review.Cureus · 2026Review
- Personalized Exercise Training Modulates Red Blood Cell Rheology and Morphology in Long COVID.International journal of molecular sciences · 2026Article
- Investigating the Hemorheological, Metabolic, and Physical Performance Effect of a Core Muscle Strengthening Training Program.Life (Basel, Switzerland) · 2025Article
- Effects of regular exercise on blood rheology.Scientific reports · 2025Article
- Hyperuricemia in Cardiac Rehabilitation Patients: Prevalence and Association with Functional Improvement and Left Ventricular Ejection Fraction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Alterations of Selected Hemorheological and Metabolic Parameters Induced by Physical Activity in Untrained Men and Sportsmen.Metabolites · 2021Article
- Exercise, Cardiovascular Health, and Risk Factors for Atherosclerosis: A Narrative Review on These Complex Relationships and Caveats of Literature.Frontiers in physiology · 2020Review
- Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity on red blood cell deformability measured in isotonic condition.Scientific reports · 2019Article
- Blood Rheology: Key Parameters, Impact on Blood Flow, Role in Sickle Cell Disease and Effects of Exercise.Frontiers in physiology · 2019Review
- A Comparison of Blood Viscosity and Hematocrit Levels between Yoga Practitioners and Sedentary Adults.International journal of exercise science · 2019Article
- Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia.Archives of medical science : AMS · 2017Article
- Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke.Frontiers in physiology · 2017Article
- Cardiac rehabilitation improves the blood plasma properties of cardiac patients.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Relationship between Changes in Fatigue and Exercise by Follow-Up Period.Korean journal of family medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
designIn this study we set out to determine the effects of long-term physical training on hemorheological, laboratory parameters, exercise tolerability, psychological factors in cardiac patients participating in an ambulatory rehabilitation program.
methodsBefore physical training, patients were examined by echocardiography, tested on treadmill by the Bruce protocol, and blood was drawn for laboratory tests. The enrolled 79 ischemic heart disease patients joined a 24-week cardiac rehabilitation training program. Blood was drawn to measure hematocrit (Hct), plasma and whole blood viscosity (PV, WBV), red blood cell (RBC) aggregation and deformability. Hemorheological, clinical chemistry and psychological measurements were repeated 12 and 24 weeks later, and a treadmill test was performed at the end of the program.
resultsAfter 12 weeks Hct, PV, WBV and RBC aggregation were significantly decreased, RBC deformability exhibited a significant increase (p<0.05). Laboratory parameters (triglyceride, uric acid, hsCRP and fibrinogen) were significantly decreased (p<0.05). After 24 weeks the significant results were still observed. By the end of the study, IL-6 and TNF-α levels displayed decreasing trends (p<0.06). There was a significant improvement in MET (p<0.001), and the BMI decrease was also significant (p<0.05). The vital exhaustion parameters measured on the fatigue impact scale indicated a significant improvement in two areas of the daily activities (p<0.05).
conclusionsRegular physical training improved the exercise tolerability of patients with ischemic heart disease. Previous publications have demonstrated that decreases in Hct and PV may reduce cardiovascular risk, while a decrease in RBC aggregation and an increase in deformability improve the capillary flow. Positive changes in laboratory parameters and body weight may indicate better oxidative and inflammatory circumstances and an improved metabolic state. The psychological findings point to an improvement in the quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.