Evidence map›Paper›PMID 25346843›Full record

ArticleChemical science2014

Uncovering divergent evolution of α/β-hydrolases: a surprising residue substitution needed to convert

David M Nedrud, Hui Lin, Gilsinia Lopez, Santosh K Padhi, Graig A Legatt, Romas J Kaz-Lauskas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

David M NedrudUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
Hui LinUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
Gilsinia LopezUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
Santosh K PadhiUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
Graig A LegattUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
Romas J Kaz-LauskasUniversity of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108 USA.
University of Minnesota · USBiotechnology Institute · USSaint Paul College · US

Funding

Evolutionary Insights Into Enzyme MechanismsR01GM102205 · NIGMS · UNIVERSITY OF MINNESOTA · PI DEAN, ANTONY M., KAZLAUSKAS, ROMAS J · 2012 to 2015
$1.8M
NIGMS NIH HHS R01 GM102205
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

catalytic promiscuitydivergent evolutionesterasehydroxynitrile lyaseprotein engineeringα/β-hydrolase

Identifiers

PMID25346843
PMCPMC4206950
OpenAlexW2027262463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.