ArticleFrontiers in microbiology2014
Comparative genomics defines the core genome of the growing N4-like phage genus and identifies N4-like Roseophage specific genes.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Novel roseophages provide insights into a genetically and ecologically diverse phage family.Microbial genomics · 2025Article
- Isolation, complete characterization and phylogeography of the first bacteriophage againstMicrobial genomics · 2025Article
- Isolation and characterization of a roseophage representing a novel genus in the N4-like Rhodovirinae subfamily distributed in estuarine waters.BMC genomics · 2025Article
- Combined metabolomic and genomic analyses reveal phage-specific and infection stage-specific alterations to marineISME communications · 2025Article
- A novel virus potentially evolved from the N4-like viruses represents a unique viral family:Applied and environmental microbiology · 2024Article
- Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor.Nature communications · 2024Article
- Genome analysis of vB_SupP_AX, a novel N4-like phage infecting Sulfitobacter.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Soil Giant Phage: Genome and Biological Characteristics ofInternational journal of molecular sciences · 2024Article
- Diversity and conservation of the genome architecture of phages infecting the Alphaproteobacteria.Microbiology spectrum · 2024Article
- Highly diverse flavobacterial phages isolated from North Sea spring blooms.The ISME journal · 2022Article
- Characterization and Genomic Analysis of the First Podophage InfectingFrontiers in microbiology · 2022Article
- Tailed Lytic Bacteriophages of Soft Rot Pectobacteriaceae.Microorganisms · 2021Review
- Prophage Genomics and Ecology in the FamilyMicroorganisms · 2021Article
- A novel vieuvirus from multidrug-resistant Acinetobacter baumannii.Archives of virology · 2021Article
- From Orphan Phage to a Proposed New Family-the Diversity of N4-Like Viruses.Antibiotics (Basel, Switzerland) · 2020Article
- Diversity ofFrontiers in microbiology · 2020Article
- Isolation and Characterization of a NovelViruses · 2019Article
- Analysis of genetic recombination and the pan-genome of a highly recombinogenic bacteriophage species.Microbial genomics · 2019Article
- Cobaviruses - a new globally distributed phage group infecting Rhodobacteraceae in marine ecosystems.The ISME journal · 2019Article
- A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types.Archives of virology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two bacteriophages, RPP1 and RLP1, infecting members of the marine Roseobacter clade were isolated from seawater. Their linear genomes are 74.7 and 74.6 kb and encode 91 and 92 coding DNA sequences, respectively. Around 30% of these are homologous to genes found in Enterobacter phage N4. Comparative genomics of these two new Roseobacter phages and 23 other sequenced N4-like phages (three infecting members of the Roseobacter lineage and 20 infecting other Gammaproteobacteria) revealed that N4-like phages share a core genome of 14 genes responsible for control of gene expression, replication and virion proteins. Phylogenetic analysis of these genes placed the five N4-like roseophages (RN4) into a distinct subclade. Analysis of the RN4 phage genomes revealed they share a further 19 genes of which nine are found exclusively in RN4 phages and four appear to have been acquired from their bacterial hosts. Proteomic analysis of the RPP1 and RLP1 virions identified a second structural module present in the RN4 phages similar to that found in the Pseudomonas N4-like phage LIT1. Searches of various metagenomic databases, including the GOS database, using CDS sequences from RPP1 suggests these phages are widely distributed in marine environments in particular in the open ocean environment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.