ArticleFrontiers in aging neuroscience2014
Primary empathy deficits in frontotemporal dementia.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.
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Who cites it
77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 163 citations in OpenAlex.
- Moral decision-making in patients with neurodegenerative diseases: a systematic review.Frontiers in psychology · 2026Pooled it
- Exploring the Relationship Between Deficits in Social Cognition and Neurodegenerative Dementia: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- Evaluation of Discriminative Detection Abilities of Social Cognition Measures for the Diagnosis of the Behavioral Variant of Frontotemporal Dementia: a Systematic Review.Neuropsychology review · 2021Pooled it
- Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.Frontiers in neurology · 2021Pooled it
- Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research.Frontiers in neurology · 2021Pooled it
- Oxytocin reduces anger bias, harm-intention recognition, and self-focus in behavioral variant frontotemporal dementia: a randomized double-blind placebo-controlled crossover trial.Frontiers in aging neuroscience · 2026Article
- Cocaine polydrug use and its impact on intentional harm recognition: a high-density EEG study.BMC psychology · 2025Article
- When empathy leads to aggression: The effects of empathy on punitive attitudes towards aggressors.The British journal of social psychology · 2025Article
- Excessive emotional reactivity in a case of behavioral variant frontotemporal dementia with amyotrophic lateral sclerosis.Psychiatry research case reports · 2025Article
- Neuroanatomical markers of social cognition in neglected adolescents.Neurobiology of stress · 2024Article
- Altered empathy processing in frontotemporal dementia A task-based fMRI study.bioRxiv : the preprint server for biology · 2024Article
- Social health markers in the context of cognitive decline and dementia: an international qualitative study.Frontiers in psychiatry · 2024Article
- The neutral past: emotional (dys)regulation of autobiographical memory in behavioural variant frontotemporal dementia.Cognitive neuropsychiatry · 2023Article
- Visual deep learning of unprocessed neuroimaging characterises dementia subtypes and generalises across non-stereotypic samples.EBioMedicine · 2023Article
- Combining Neuropsychological Assessment with Neuroimaging to Distinguish Early-Stage Alzheimer's Disease from Frontotemporal Lobar Degeneration in Non-Western Tonal Native Language-Speaking Individuals Living in Taiwan: A Case Series.Journal of clinical medicine · 2023Article
- Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study.Lancet regional health. Americas · 2023Article
- Can prosocial values improve brain health?Frontiers in neurology · 2023Article
- Moral Emotions and Their Brain Structural Correlates Across Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2023Article
- The impact of breast cancer on social cognition in female Colombian patients.BMC psychology · 2022Article
- Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study.BMC neurology · 2022Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of empathy is an early central symptom and diagnostic criterion of the behavioral variant frontotemporal dementia (bvFTD). Although changes in empathy are evident and strongly affect the social functioning of bvFTD patients, few studies have directly investigated this issue by means of experimental paradigms. The current study assessed multiple components of empathy (affective, cognitive and moral) in bvFTD patients. We also explored whether the loss of empathy constitutes a primary deficit of bvFTD or whether it is explained by impairments in executive functions (EF) or other social cognition domains. Thirty-seven bvFTD patients with early/mild stages of the disease and 30 healthy control participants were assessed with a task that involves the perception of intentional and accidental harm. Participants were also evaluated on emotion recognition, theory of mind (ToM), social norms knowledge and several EF domains. BvFTD patients presented deficits in affective, cognitive and moral aspects of empathy. However, empathic concern was the only aspect primarily affected in bvFTD that was neither related nor explained by deficits in EF or other social cognition domains. Deficits in the cognitive and moral aspects of empathy seem to depend on EF, emotion recognition and ToM. Our findings highlight the importance of using tasks depicting real-life social scenarios because of their greater sensitivity in the assessment of bvFTD. Moreover, our results contribute to the understanding of primary and intrinsic empathy deficits of bvFTD and have important theoretical and clinical implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.