Evidence map›Paper›PMID 25346568›Full record

ArticleSeminars in hearing2012

Vascular Pathophysiology in Hearing Disorders.

Dennis R Trune, Anh Nguyen-Huynh

Open access · greenAbstract read
In one paragraph

Article in Seminars in hearing, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  3. Pooled it
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Prevalence of self-perceived audiovestibular symptoms in Egyptian COVID-19 patients.The Journal of the Egyptian Public Health Association · 2023
    Article
  15. Article
  16. Better late than never: initial experience of intra-arterial pulsed-urokinase-injection as a salvage therapy for refractory sudden sensorineural hearing loss.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Article
  17. Article
  18. A High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice.International journal of molecular sciences · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dennis R TruneOregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery Oregon Health & Science University, Portland, OR 97239 USA.
Anh Nguyen-HuynhOregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery Oregon Health & Science University, Portland, OR 97239 USA.
Oregon Health & Science University · US

Funding

PORTLAND AREA COMMUNICATION RESEARCH CORE CENTERP30DC005983 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NUTTALL, ALFRED L · 2003 to 2017
$9.0M
Steroid Responsive Mechanisms in the EarR01DC005593 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI TRUNE, DENNIS ROYAL · 2002 to 2012
$5.2M
NIDCD NIH HHS P30 DC005983NIDCD NIH HHS R01 DC005593
6 · The paper itself

Abstract

The inner ear vasculature is responsible for maintenance of the blood-labyrinth barrier, transport of systemic hormones for ion homeostasis, and supplying nutrients for metabolic functions. Unfortunately, these blood vessels also expose the ear to circulating inflammatory factors resulting from systemic diseases. Thus, while the inner ear blood vessels are critical for normal function, they also are facilitating pathologic mechanisms that result in hearing and vestibular dysfunction. In spite of these numerous critical roles of inner ear vasculature, little is known of its normal homeostatic functions and how these are compromised in disease. The objective of this review is to discuss the current concepts of vascular biology, how blood vessels naturally respond to circulating inflammatory factors, and how such mechanisms of vascular pathophysiology may cause hearing loss.

Indexed as

blood-labyrinth barrierblood vesselsglycocalyxhearing lossimmunopathology

Identifiers

PMID25346568
PMCPMC4208101
OpenAlexW2111730362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.