ArticleNephrology (Carlton, Vic.)2015
Physical activity and risk of end-stage kidney disease in the Singapore Chinese Health Study.
Article in Nephrology (Carlton, Vic.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Physical activity and risk of chronic kidney disease: systematic review and meta-analysis of 12 cohort studies involving 1,281,727 participants.European journal of epidemiology · 2023Pooled it
- Sedentary behavior and kidney function in adults: a narrative review.Wiener klinische Wochenschrift · 2021Pooled it
- Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis.Journal of the American Society of Nephrology : JASN · 2021Pooled it
- Asian Pacific Society of Nephrology Clinical Practice Guideline on Diabetic Kidney Disease-2025 Update.Nephrology (Carlton, Vic.) · 2025Article
- Healthy lifestyle factors as predictors of the initiation of dialysis in people with and without diabetes.Diabetology international · 2024Article
- Association of physical activity with risk of chronic kidney disease in China: A population-based cohort study.Journal of sport and health science · 2024Article
- Association between questionnaire-based and accelerometer-based physical activity and the incidence of chronic kidney disease using data from UK Biobank: a prospective cohort study.EClinicalMedicine · 2023Article
- Association between sedentary behavior and chronic kidney disease in Korean adults.BMC public health · 2023Article
- Joint Associations of Multiple Lifestyle Factors With Risk of Active Tuberculosis in the Population: The Singapore Chinese Health Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Associations of kidney tests at medical facilities and health checkups with incidence of end-stage kidney disease: a retrospective cohort study.Scientific reports · 2021Article
- Association Between Combined Lifestyle Factors and Healthy Ageing in Chinese Adults: The Singapore Chinese Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Healthful dietary patterns and risk of end-stage kidney disease: the Singapore Chinese Health Study.The American journal of clinical nutrition · 2021Article
- Impact of Combined Lifestyle Factors on All-Cause and Cause-Specific Mortality and Life Expectancy in Chinese: The Singapore Chinese Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Linking disease registries and nationwide healthcare administrative databases: the French renal epidemiology and information network (REIN) insight.BMC nephrology · 2020Article
- The Pre-Dialysis Care Trajectory of Chronic Kidney Disease Patients and the Start of Dialysis in Emergency: A Mixed Method Study Protocol.International journal of environmental research and public health · 2019Article
- Pulse Pressure and the Risk of End-Stage Renal Disease Among Chinese Adults in Singapore: The Singapore Chinese Health Study.Journal of the American Heart Association · 2019Article
- The association of exercise and sedentary behaviours with incident end-stage renal disease: the Southern Community Cohort Study.BMJ open · 2019Article
- Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study.Sleep medicine · 2019Article
- Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians.Scientific reports · 2018Article
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Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
aimTo explore the relationship between physical activity and risk of end-stage kidney disease (ESKD).
methodsWe analysed data on a prospective cohort of 59,552 Chinese adults aged 45-74 years enrolled in the Singapore Chinese Health Study. Information on physical activity was collected with a structured questionnaire. Physically active individuals were defined as those who engaged in any moderate activities for 2 h or more per week and any strenuous activities 30 min or more per week. Incident ESKD was identified via record linkage with the Singapore Registry of Birth and Death and Singapore Renal Registry. Cox proportional hazards regression method was used for analysis for risk of incident ESKD alone or ESKD plus death associated with physical activity.
resultsDuring a median follow-up of 15.3 years, a total of 642 incident ESKD occurred, and 9808 study participants died. A 24% lower adjusted risk of ESKD (hazard ratio: 0.76; 95% confidence interval: 0.62-0.93) was associated with moderate or strenuous physical activities compared with no regular physical activity. This association appeared to be dose dependent with the lowest risk for subjects at highest intensity of physical activity (P trend <0.003). Similar results were observed for risk of ESKD plus death.
conclusionHigher levels of physical activity are associated with lower risk of ESKD. Our findings highlight the role of physical activity for prevention of ESKD, which deserves further evaluation in intervention trials.
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