Evidence map›Paper›PMID 25345994›Full record

ArticlePediatric blood & cancer2015

Why pediatric patients with cancer visit the emergency department: United States, 2006-2010.

Emily L Mueller, Amber Sabbatini, Achamyeleh Gebremariam, Rajen Mody, Lillian Sung, Michelle L Macy

Erratum issued Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Pediatric blood & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03449693 (Efficacy of Oral Supplementation With Magnesium to Reduce Febrile Neutropenia in Pediatric Oncology Patients Treated With Cisplatin-Based Chemotherapy), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03449693 phase2unknown statusnot on this mapstarted 2017, after this paper: background citation

Efficacy of Oral Supplementation With Magnesium to Reduce Febrile Neutropenia in Pediatric Oncology Patients Treated With Cisplatin-Based Chemotherapy: Randomized Clinical Trial

TypeinterventionalSponsorUniversidad Nacional Autonoma de MexicoRan2017 to 2019Enrolled214ConditionsFebrile NeutropeniaArmsMagnesium Oxide Supplement
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 69 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Emily L MuellerDepartment of Pediatrics and Communicable Diseases, Division of Pediatric Hematology Oncology, University of Michigan, Ann Arbor, Michigan; Department of Pediatrics and Communicable Diseases, Child Health Evaluation and Research (CHEAR) Unit, Division of General Pediatrics, University of Michigan, Ann Arbor, Michigan.
Amber Sabbatini
Achamyeleh Gebremariam
Rajen Mody
Lillian Sung
Michelle L Macy
University of Michigan · USHospital for Sick Children · CA

Funding

UW Patient-Centered Outcomes Research Career Development Program K12 2014 2019K12HS022982 · AHRQ · UNIVERSITY OF WASHINGTON · PI SULLIVAN, SEAN D · 2014 to 2018
$3.8M
PEDIATRIC HEALTH SERVICES RESEARCH TRAININGT32HD007534 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVIS, MATTHEW M · 2000 to 2014
$3.7M
AHRQ HHS K12 HS022982NICHD NIH HHS T32 HD007534NICHD NIH HHS T32 HD07534
6 · The paper itself

Abstract

backgroundLittle is known about emergency department (ED) use among pediatric patients with cancer. We explored reasons prompting ED visits and factors associated with hospital admission. PROCEDURE: A retrospective cohort analysis of pediatric ED visits from 2006 to 2010 using the Nationwide Emergency Department Sample, the largest all-payer database of United States ED visits. Pediatric patients with cancer (ages ≤19 years) were identified using Clinical Classification Software. Proportion of visits and disposition for the top ten-ranking non-cancer diagnoses were determined. Weighted multivariate logistic regression was performed to analyze factors associated with admission versus discharge.

resultsThere were 294,289 ED visits by pediatric patients with cancer in the U.S. over the study period. Fever and fever with neutropenia (FN) were the two most common diagnoses, accounting for almost 20% of visits. Forty-four percent of pediatric patients with cancer were admitted to the same hospital, with admission rates up to 82% for FN. Risk factors for admission were: FN (odds ratio (OR) 8.58; 95% confidence interval (CI) 5.97-12.34); neutropenia alone (OR 7.28; 95% CI 5.08-10.43), ages 0-4 years compared with 15-19 years (OR 1.19; 95% CI 1.08-1.31) and highest median household income ZIP code (OR 1.27; 95% CI 1.08-1.49) compared with lowest. "Self-pay" visits had lower odds of admission (OR 0.42; 95% CI 0.35-0.51) compared with public payer.

conclusionFN was the most common reason for ED visits among pediatric patients with cancer and is the condition most strongly associated with admission. Socioeconomic factors appear to influence ED disposition for this population.

Indexed as

Databases, FactualEmergency Medical ServicesEmergency Service, HospitalFebrile NeutropeniaModels, BiologicalSoftwareAdolescentAdultAge FactorsChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleemergency servicefebrile neutropeniahealth care surveysoncologysupportive careUnited States

Identifiers

PMID25345994
PMCPMC4304987
OpenAlexW2113072198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.