ArticleBritish journal of clinical pharmacology2015
Hormonal contraceptive use and risk of glioma among younger women: a nationwide case-control study.
Article in British journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Oral Contraceptive and Glioma Risk: A Prospective Cohort Study and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.BMC cancer · 2020Pooled it
- Update on the effect of exogenous hormone use on glioma risk in women: a meta-analysis of case-control and cohort studies.Journal of neuro-oncology · 2018Pooled it
- Environmental Hazards and Glial Brain Tumors: Association or Causation?International journal of molecular sciences · 2025Review
- Article
- Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study.Scientific reports · 2023Article
- Article
- Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones.Biology of sex differences · 2021Review
- Astrocytoma: A Hormone-Sensitive Tumor?International journal of molecular sciences · 2020Review
- Risk of primary brain tumour after breast cancer.Endocrine connections · 2020Article
- Reproductive epidemiology of glial tumors may reveal novel treatments: high-dose progestins or progesterone antagonists as endocrino-immune modifiers against glioma.Neurosurgical review · 2019Review
- Use of MendelianFrontiers in genetics · 2018Review
- Cancer risk among parous women following assisted reproductive technology.Human reproduction (Oxford, England) · 2015Article
- Does exogenous hormonal therapy affect the risk of glioma among females: A systematic review and meta-analysis.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOral contraceptive use influences the risk for certain cancers. However, few studies have examined any link with risk of central nervous system tumours. We investigated the association between hormonal contraceptive use and glioma risk among premenopausal women in a population-based setting.
methodsUsing national administrative and health registries in Denmark to conduct a nationwide case-control study, we identified all women ages 15 to 49 years with a first time diagnosis of histologically verified glioma between 2000 and 2009. Each case was age-matched to eight population controls using risk set sampling. Based on prescription data, exposure until 2 years prior to the index date was categorized according to hormonal contraceptive type, i.e. combined oestrogen-progestagen or progestagen only, and duration of use (<1, 1 to <5, ≥5 years). We used conditional logistic regression to compute odds ratios (ORs) with 95% confidence intervals (CIs) for glioma associated with hormonal contraceptive use, adjusting for potential confounders.
resultsWe identified 317 cases and 2126 controls. Ever use of hormonal contraceptive was associated with an OR of 1.5 (95% CI 1.2, 2.0) and the OR increased with duration of use (long term, ≥5 years: OR 1.9; 95% CI 1.2, 2.9). The association between long term hormonal contraceptive use and glioma risk was most pronounced for progestagen only therapy (OR 2.4; 95% CI 1.1, 5.1), especially when this regimen constituted the sole hormonal contraceptive therapy (OR 4.1; 95% CI 0.8, 20.8).
conclusionLong term hormonal contraceptive use may increase the risk of glioma.
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Registered trials
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