Evidence map›Paper›PMID 25345742›Full record

ArticleActa pharmacologica Sinica2014

Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway.

Hong Xie, Jing Zhang, Jiang Zhu, Li-xin Liu, Mario Rebecchi, Su-mei Hu, Chen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong XieDepartment of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Jing ZhangInstitute of Neuroscience, Soochow University, Suzhou 215000, China.
Jiang ZhuDepartment of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Li-xin LiuDepartment of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.
Mario RebecchiDepartment of Anesthesiology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.
Su-mei HuDepartment of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Chen Wang1] Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China [2] Institute of Neuroscience, Soochow University, Suzhou 215000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the role of extracellular signal-regulated kinases (ERKs) in sevoflurane post-conditioning induced cardioprotection in vitro.

methodsIsolated rat hearts were subjected to 30 min ischemia followed by 120 min reperfusion (I/R). Sevoflurane post-conditioning was carried out by administration of O2-enriched gas mixture with 3% sevoflurane (SEVO) for 15 min from the onset of reperfusion. Cardiac functions, myocardial infarct size, myocardial ATP and NAD(+) contents, mitochondrial ultrastructure, and anti-apototic and anti-oncosis protein levels were measured.

resultsSevoflurane post-conditioning significantly improved the heart function, decreased infarct size and mitochondria damage, and increased myocardial ATP and NAD(+) content in the I/R hearts. Furthermore, sevoflurane post-conditioning significantly increased the levels of p-ERK and p-p70S6K, decreased the levels of porimin, caspase-8, cleaved caspase-3, and cytosolic cytochrome c in the I/R hearts. Co-administration of the ERK1/2 inhibitor PD98059 (20 μmol/L) abolished the sevoflurane-induced protective effects against myocardial I/R.

conclusionSevoflurane post-conditioning protects isolated rat hearts against myocardial I/R injury and inhibits cell oncosis and apoptosis via activation of the ERK1/2 pathway.

Indexed as

Adenosine TriphosphateAnimalsApoptosisApoptosis Regulatory ProteinsCardiotonic AgentsCytoprotectionDisease Models, AnimalEnzyme ActivationHeart RateMaleMAP Kinase Signaling SystemMethyl EthersMitochondria, HeartMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Myocardial ContractionAdenosine TriphosphateApoptosis Regulatory ProteinsCardiotonic AgentsMapk1 protein, ratMethyl EthersMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NADProtein Kinase InhibitorsSevoflurane

Identifiers

PMID25345742
PMCPMC4261124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.