ArticleJournal of biomedical materials research. Part A2015
A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion.
Article in Journal of biomedical materials research. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 77 citations in OpenAlex.
- Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.Pharmaceutics · 2026Review
- An Overview of Advanced Materials and Manufacturing Strategies for 3D-Printed Bioengineered Vascular Stents: Toward Next-Generation Drug Delivery Applications.Pharmaceutics · 2026Review
- Review
- Programming Degradation and Drug Release Through Micropatterning of PLGA Films.ACS applied materials & interfaces · 2026Article
- PLGA-Based Co-Delivery Nanoformulations: Overview, Strategies, and Recent Advances.Pharmaceutics · 2025Review
- A Numerical Study on the Drug Release Process of Biodegradable Polymer Drug-Loaded Vascular Stents.Polymers · 2025Article
- A Strategy for the In-Silico Assessment of Drug Eluting Stents: A Comparative Study for the Evaluation of Retinoic Acid as a Novel Drug Candidate for Drug Eluting Stents.IEEE open journal of engineering in medicine and biology · 2025Article
- A "built-up" composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility.Bioactive materials · 2023Article
- Comprehensive review of materials, applications, and future innovations in biodegradable esophageal stents.Frontiers in bioengineering and biotechnology · 2023Review
- Noncoding RNAs in Vascular Cell Biology and Restenosis.Biology · 2022Review
- Artificial intelligence in the analysis of glycosylation data.Biotechnology advances · 2022Review
- Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles.Science advances · 2022Article
- Review
- Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review.Pharmaceutics · 2022Review
- Three-dimensional mesenchymal stem cell laden scaffold of icariin sustained-release for bone regeneration.Turkish journal of biology = Turk biyoloji dergisi · 2022Article
- Heparin-Tagged PLA-PEG Copolymer-Encapsulated Biochanin A-Loaded (Mg/Al) LDH Nanoparticles Recommended for Non-Thrombogenic and Anti-Proliferative Stent Coating.International journal of molecular sciences · 2021Article
- New Insight into the Mechanism of Drug Release from Poly(d,l-lactide) Film by Electron Paramagnetic Resonance.Polymers · 2020Article
- Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release.Scientific reports · 2020Article
- A Computational Model for Drug Release from PLGA Implant.Materials (Basel, Switzerland) · 2018Article
- Hollow Microparticles as a Superior Delivery System over Solid Microparticles for the Encapsulation of Peptides.Pharmaceutical research · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in delivering drug for reducing stents-related side effects. In this work, a mathematical model for describing the PLGA degradation and erosion and coupled drug release from PLGA stent coating is developed and validated. An analytical expression is derived for PLGA mass loss that predicts multiple experimental studies in the literature. An analytical model for the change of the number-average degree of polymerization [or molecular weight (MW)] is also derived. The drug transport model incorporates simultaneous drug diffusion through both the polymer solid and the liquid-filled pores in the coating, where an effective drug diffusivity model is derived taking into account factors including polymer MW change, stent coating porosity change, and drug partitioning between solid and aqueous phases. The model is used to describe in vitro sirolimus release from PLGA stent coating, and demonstrates the significance of simultaneous sirolimus release via diffusion through both polymer solid and pore space. The proposed model is compared to existing drug transport models, and the impact of model parameters, limitations and possible extensions of the model are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.