ReviewNeurosurgical review2015
DTI-MRI biomarkers in the search for normal pressure hydrocephalus aetiology: a review.
Review in Neurosurgical review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.Neurologia medico-chirurgica · 2021Guideline
- Clinical Improvement after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus Can Be Quantified by Diffusion Tensor Imaging.AJNR. American journal of neuroradiology · 2025Article
- Impact of the Ventricle Size on Alzheimer's Disease Progression: A Retrospective Longitudinal Study.Dementia and neurocognitive disorders · 2024Article
- Ventricular CSF proteomic profiles and predictors of surgical treatment outcome in chronic hydrocephalus.Acta neurochirurgica · 2023Article
- Clinical and MRI features of gait and balance disorders in neurodegenerative diseases.Journal of neurology · 2023Review
- Radiological biomarkers of idiopathic normal pressure hydrocephalus: new approaches for detecting concomitant Alzheimer's disease and predicting prognosis.Psychoradiology · 2022Review
- The splenial angle: a novel radiological index for idiopathic normal pressure hydrocephalus.European radiology · 2021Article
- The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.The neuroradiology journal · 2021Review
- Dynamic functional networks in idiopathic normal pressure hydrocephalus: Alterations and reversibility by CSF tap test.Human brain mapping · 2021Article
- Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage.Neuroscience bulletin · 2020Article
- Injury of Corticospinal Tract in a Patient with Subarachnoid Hemorrhage as Determined by Diffusion Tensor Tractography: A Case Report.Brain sciences · 2020Article
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
- Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus.PloS one · 2017Article
- Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus.Fluids and barriers of the CNS · 2016Article
- Article
- A Review of Clinical Outcomes for Gait and Other Variables in the Surgical Treatment of Idiopathic Normal Pressure Hydrocephalus.Movement disorders clinical practiceReview
- Neuroimaging in normal pressure hydrocephalus.Dementia & neuropsychologiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal pressure hydrocephalus (NPH) is a clinical syndrome characterized by gait disturbances, urinary incontinence and dementia. Clinical presentation overlaps with Alzheimer disease (AD). Early recognition thus early intervention (shunting) is important for successful treatment, but lack of a diagnostic test with sufficient sensitivity and specificity complicates the diagnosis. We performed literature search and composed a structured review of imaging biomarkers of NPH. Morphometric studies are not sufficient to diagnose NPH. Hydrocephalus is a common finding in elderly people due to the symmetric brain atrophy and is even more pronounced in patients with AD. The key MRI biomarker seems to be diffusion tensor imaging (DTI). According to recent studies, the DTI analysis of the splenium corporis callosi, posterior limb of internal capsule, hippocampus and fornix combined with measurement of Evans index is a promising MRI biomarker of NPH and could be used for NPH diagnostics and in the differential diagnosis from AD and other dementias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.