Evidence map›Paper›PMID 25344944›Full record

Trial reportSocial cognitive and affective neuroscience2015

Neural changes with attention bias modification for anxiety: a randomized trial.

Jennifer C Britton, Jenna G Suway, Michelle A Clementi, Nathan A Fox, Daniel S Pine, Yair Bar-Haim

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03283930 (A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03283930 nacompletednot on this mapstarted 2016, after this paper: background citation

A Clinical Trial of a Gamified Attention Bias Modification Training in Anxious Youth

TypeinterventionalSponsorNational Institutes of Health Clinical Center (CC)Ran2016 to 2023Enrolled121ConditionsAnxiety DisordersArmsActive Attention Bias Modification Training, Placebo Attention Bias Modification Training
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  9. Article
  10. Novel mechanism-based treatments for pediatric anxiety and depressive disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  11. Article
  12. Attentional biases in human anxiety.Neuroscience and biobehavioral reviews · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Neural correlates of cognitive bias modification for interpretation.Social cognitive and affective neuroscience · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jennifer C BrittonSection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel Section on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel j.britton@miami.edu.
Jenna G SuwaySection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel Section on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel.
Michelle A ClementiSection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel Section on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel.
Nathan A FoxSection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel.
Daniel S PineSection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel.
Yair Bar-HaimSection on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892 USA, Department of Psychology, University of Miami, Coral Gables, FL, 33146 USA, Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742 USA, Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, San Diego, CA, 92120 USA, Department of Psychology, University of Houston, Houston, TX, 77204 USA, and School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 69978 Israel.
National Institute of Mental Health · USSan Diego State University · USUniversity of California, San Diego · USUniversity of Houston · USUniversity of Maryland, College Park · US

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Project 3: The neurobiology of adverse early care in rhesus infants....P50MH078105 · NIMH · UNIVERSITY OF MINNESOTA · PI GUNNAR, MEGAN R · 2009 to 2013
$9.9M
Neuroimaging of Extinction Recall in Development and Adolescent Social AnxietyR00MH091183 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI BRITTON, JENNIFER CHRISTINA · 2012 to 2014
$708k
Intramural NIH HHSNIMH NIH HHS P50 MH078105NIMH NIH HHS R00 MH091183
6 · The paper itself

Abstract

Attention bias modification (ABM) procedures typically reduce anxiety symptoms, yet little is known about the neural changes associated with this behavioral treatment. Healthy adults with high social anxiety symptoms (n = 53) were randomized to receive either active or placebo ABM. Unlike placebo ABM, active ABM aimed to train individuals' attention away from threat. Using the dot-probe task, threat-related attention bias was measured during magnetic resonance imaging before and after acute and extended training over 4 weeks. A subset of participants completed all procedures (n = 30, 15 per group). Group differences in neural activation were identified using standard analyses. Linear regression tested predictive factors of symptom reduction (i.e., training group, baseline indices of threat bias). The active and placebo groups exhibited different patterns of right and left amygdala activation with training. Across all participants irrespective of group, individuals with greater left amygdala activation in the threat-bias contrast prior to training exhibited greater symptom reduction. After accounting for baseline amygdala activation, greater symptom reduction was associated with assignment to the active training group. Greater left amygdala activation at baseline predicted reductions in social anxiety symptoms following ABM. Further research is needed to clarify brain-behavior mechanisms associated with ABM training.

Indexed as

AdolescentAdultAmygdalaAnxiety DisordersAttentionCognitive Behavioral TherapyEmotionsFaceFacial ExpressionFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPsychomotor Performanceamygdalaanxietyattention trainingdot-probefMRItreatment

Identifiers

PMID25344944
PMCPMC4483563
OpenAlexW2152264519

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.