ArticleInternational journal of epidemiology2015
Cohort Profile: Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) prospective cohort study.
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The trial behind it
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Who cites it
38 citing papers in PubMed.
- Differential associations of oxidative stress parameters with neuroendocrine markers and hemodynamic reactivity in acute mental stress-induced adrenergic reactivity profiles: The SABPA study.Physiological reports · 2026Article
- Resting neuroendocrine markers in relation to acute mental stress-induced adrenergic reactivity profiles in adults: The SABPA study.Physiological reports · 2026Article
- The Relationship Between Resting Heart Rate and Cardiovascular Risk Factors Among Adults Aged 18 Years and Above in the Rural Ellisras Population: Ellisras Longitudinal Study.Journal of cardiovascular development and disease · 2025Article
- Acute mental stress-induced alpha or beta-adrenergic reactivity patterns linked to unique cardiometabolic risk profiles.Scientific reports · 2025Article
- Variable heteroplasmy of the Common 9-bp Deletion in the Human Mitochondrial Genome in Ancient and Present-Day Populations.microPublication biology · 2025Article
- Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- The relationship between physical activity, body fatness and metabolic syndrome in urban South African school teachers: The sympathetic activity and ambulatory blood pressure in Africans study.African journal of primary health care & family medicine · 2022Article
- The Role of Physical Activity Status in the Relationship between Obesity and Carotid Intima-Media Thickness (CIMT) in Urban South African Teachers: The SABPA Study.International journal of environmental research and public health · 2022Article
- Mitochondrial DNA variation in Parkinson's disease: Analysis of "out-of-place" population variants as a risk factor.Frontiers in aging neuroscience · 2022Article
- The Chronic Kidney Disease in Africa (CKD-Africa) collaboration: lessons from a new pan-African network.BMJ global health · 2021Article
- Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study.Journal of human hypertension · 2021Article
- A Stress Syndrome Prototype Reflects Type 3 Diabetes and Ischemic Stroke Risk: The SABPA Study.Biology · 2021Article
- Circulating neurotrophins and hemostatic risk factors of atherothrombotic cardiovascular disease at baseline and during sympathetic challenge: the SABPA study.Scientific reports · 2021Article
- Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain-retina-heart link: the SABPA study.Eye (London, England) · 2020Article
- Vascular Structure and Inflammation in a South African Population: The SABPA Study.Pulse (Basel, Switzerland) · 2020Article
- Retinal-glia ischemia and inflammation induced by chronic stress: The SABPA study.Brain, behavior, & immunity - health · 2020Article
- Ambulatory blood pressure monitoring and morning surge in blood pressure in adult black and white South Africans.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Three-year change in oxidative stress markers is linked to target organ damage in black and white men: the SABPA study.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Copeptin relates to a fatty liver and measures of obesity in a South African population with mixed ethnicities.Endocrine · 2019Article
- Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: The SABPA study.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Adapting to an over-demanding stressful urban environment may exhaust the psychophysiological resources to cope with these demands, and lead to sympathetic nervous system dysfunction. The evidence that an urban-dwelling lifestyle may be detrimental to the cardiometabolic health of Africans motivated the design of the Sympathetic activity and Ambulatory Blood Pressure in African Prospective cohort study. We aimed to determine neural mechanistic pathways involved in emotional distress and vascular remodelling. The baseline sample included 409 teachers representing a bi-ethnic sex cohort from South Africa. The study was conducted in 2008-09 and repeated after 3-year follow-up in 2011-12, with an 87.8% successful follow-up rate. Seasonal changes were avoided and extensive clinical assessments were performed in a well-controlled setting. Data collection included sociodemographics, lifestyle habits, psychosocial battery and genetic analysis, mental stress responses mimicking daily life stress (blood pressure and haemostatic, cardiometabolic, endothelial and stress hormones). Target organ damage was assessed in the brain, heart, kidney, blood vessels and retina. A unique highly phenotyped cohort is presented that can address the role of a hyperactive sympathetic nervous system and neural response pathways contributing to the burden of cardiometabolic diseases in Africans.
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