ArticleVirchows Archiv : an international journal of pathology2015
Squamous/epidermoid differentiation in normal breast and salivary gland tissues and their corresponding tumors originate from p63/K5/14-positive progenitor cells.
Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Low-Grade Adenosquamous Carcinoma of the Breast: A Single-Center Retrospective Study and a Systematic Literature Review.Cancers · 2024Article
- Clear cell hidradenoma of the breast with MAML2 gene rearrangement.Pathology international · 2024Article
- Clinicopathological Features of 26 Intraoral Polymorphous Adenocarcinomas from a Single Brazilian Institution.Head and neck pathology · 2024Article
- Syringomatous adenoma of the nipple: A case series and systematic review.Clinical case reports · 2023Article
- Pancreatic Adenosquamous Carcinoma: A Rare Pathological Subtype of Pancreatic Cancer.Journal of clinical medicine · 2022Review
- Breast carcinomas of low malignant potential.Virchows Archiv : an international journal of pathology · 2022Review
- A Global Vista of the Epigenomic State of the Mouse Submandibular Gland.Journal of dental research · 2021Article
- [Pathology of the nipple-areola complex : Part II. Tumors, tumor-like lesions, and supernumerary breast lesions].Der Pathologe · 2020Review
- The Expression Pattern of Epidermal Differentiation Marker Keratin 10 in the Normal Human Breast and Breast Cancer Cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept.Histochemistry and cell biology · 2020Article
- VDR in salivary gland homeostasis and cancer.The Journal of steroid biochemistry and molecular biology · 2020Article
- Challenges in Minor Salivary Gland Biopsies: A Practical Approach to Problematic Histologic Patterns.Head and neck pathology · 2019Review
- Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Metaplastic breast carcinoma composed of epithelial-myoepithelial carcinoma and squamous cell carcinoma: A case report.Medicine · 2018Article
- Identification of autofluorescent cells in human angioimmunoblastic T-cell lymphoma.Histochemistry and cell biology · 2018Article
- Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast: A case report.Medicine · 2017Article
- Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.Virchows Archiv : an international journal of pathology · 2017Observational
- Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and human papilloma virus co-receptor expression.Oncotarget · 2016Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A small group of tumors of breast and salivary glands contains squamous/epidermoid elements as a constitutive feature (e.g., squamous carcinoma, syringomatous tumors, and mucoepidermoid carcinoma). Other tumors (e.g., pleomorphic adenoma, adenomyoepithelial tumors, and adenoid cystic carcinoma) may show occasionally squamous differentiation. Furthermore, squamous metaplasia may be observed in non-neoplastic breast and salivary tissues. However, the histogenesis of these squamous differentiations is far from being understood. Based on our earlier in situ triple immunofluorescence and quantitative reverse transcription (RT)-PCR experiments for basal keratins K5/14 and p63 as well as for glandular keratins (K7/K8/18), squamous keratins (K10 and K13), and myoepithelial lineage markers (smooth muscle actin, SMA), we here traced the squamous/epidermoid differentiation lineage of 60 tumors of the breast and/or salivary glands, cultured tumor cells of 2 tumors, and of 7 squamous metaplasias of non-neoplastic breast and salivary tissues. Our results indicate that both the neoplastic lesions as well as the non-neoplastic squamous metaplasia contain p63/K5/14+ cells that differentiate toward K10/13+ squamous cells. Thus, cells with squamous/epidermoid differentiation undergo a transition from its original p63/K5/14+ precursor state to K10/13+ squamous lineage state, which can be pictured by triple-immunofluorescence experiments. Given the immunophenotypic similarity of p63/K5/14+ tumor cells to their physiological p63/K5/14+ counterparts in normal breast and salivary duct epithelium, we suggest that these cells provide an important histogenetic key to understanding the pathogenesis of squamous differentiation both in normal breast/salivary gland tissues and their corresponding tumors.
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