ArticleOncotarget2014
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1.Oncogene · 2024Article
- Opposite roles of Kindlin orthologs in cell survival and proliferation.Cell proliferation · 2022Article
- New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome.Cellular and molecular life sciences : CMLS · 2022Article
- FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling.Respiratory research · 2021Article
- Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer.BMC medical genomics · 2021Article
- Kindlins as modulators of breast cancer progression.Journal of breast cancer research · 2021Article
- High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer.Frontiers in oncology · 2021Article
- miR-4792 Inhibits Acute Myeloid Leukemia Cell Proliferation and Invasion and Promotes Cell Apoptosis by Targeting Kindlin-3.Oncology research · 2020Article
- Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state.PLoS biology · 2020Article
- Review
- Comparative Analysis of the Transcriptome and Proteome during Mouse Placental Development.Journal of proteome research · 2019Article
- Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells.Life science alliance · 2019Article
- Distinct expression profiles and functions of Kindlins in breast cancer.Journal of experimental & clinical cancer research : CR · 2018Article
- Prognostic value of NUSAP1 in progression and expansion of glioblastoma multiforme.Journal of neuro-oncology · 2018Article
- Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis.Cell adhesion & migration · 2017Article
- Prognostic implications of Kindlin proteins in human osteosarcoma.OncoTargets and therapy · 2017Article
- NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.PloS one · 2016Article
- Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells.Scientific reports · 2015Article
- High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma.Oncotarget · 2015Article
- Of Kindlins and Cancer.Discoveries (Craiova, Romania)Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kindlin-3 (FERMT-3) is known to be central in hemostasis and thrombosis control and its deficiency disrupts platelet aggregation and causes Leukocyte Adhesion Deficiency disease. Here we report that Kindlin-3 has a tumor suppressive role in solid cancer. Our present genetic and functional data show that Kindlin-3 is downregulated in several solid tumors by a mechanism involving gene hypermethylation and deletions. In vivo experiments demonstrated that Kindlin-3 knockdown in 2 tumor cell models (breast cancer and melanoma) markedly increases metastasis formation, in accord with the in vitro increase of tumor cell malignant properties. The metastatic phenotype was supported by a mechanism involving alteration in β3-integrin activation including decreased phosphorylation, interaction with talin and the internalization of its active form leading to less cell attachment and more migration/invasion. These data uncover a novel and unexpected tumor suppressor role of Kindlin-3 which can influence integrins targeted therapies development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.