Evidence map›Paper›PMID 25344849›Full record

ReviewTransgenic research2015

A comparative analysis of insertional effects in genetically engineered plants: considerations for pre-market assessments.

Jaimie Schnell, Marina Steele, Jordan Bean, Margaret Neuspiel, Cécile Girard, Nataliya Dormann, Cindy Pearson, Annie Savoie, Luc Bourbonnière, Philip Macdonald

Open access · hybridAbstract readReview
In one paragraph

Review in Transgenic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 139 citations in OpenAlex.

  1. Article
  2. Review
  3. Evolution of the Canadian regulatory system for plant biotechnology.Frontiers in bioengineering and biotechnology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. One risk assessment for genetically modified plants.Frontiers in bioengineering and biotechnology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Dietary Behavior ofJournal of xenobiotics · 2021
    Article
  16. Influence of transgenesis on genome variability in cucumber lines with aPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Impacts of the regulatory environment for gene editing on delivering beneficial products.In vitro cellular & developmental biology. Plant : journal of the Tissue Culture Association · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jaimie SchnellPlant and Biotechnology Risk Assessment Unit, Canadian Food Inspection Agency, 1400 Merivale Road, Ottawa, ON, K1A 0Y9, Canada, jaimie.schnell@inspection.gc.ca.
Marina Steele
Jordan Bean
Margaret Neuspiel
Cécile Girard
Nataliya Dormann
Cindy Pearson
Annie Savoie
Luc Bourbonnière
Philip Macdonald
Canadian Food Inspection Agency · CAHealth Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During genetic engineering, DNA is inserted into a plant's genome, and such insertions are often accompanied by the insertion of additional DNA, deletions and/or rearrangements. These genetic changes are collectively known as insertional effects, and they have the potential to give rise to unintended traits in plants. In addition, there are many other genetic changes that occur in plants both spontaneously and as a result of conventional breeding practices. Genetic changes similar to insertional effects occur in plants, namely as a result of the movement of transposable elements, the repair of double-strand breaks by non-homologous end-joining, and the intracellular transfer of organelle DNA. Based on this similarity, insertional effects should present a similar level of risk as these other genetic changes in plants, and it is within the context of these genetic changes that insertional effects must be considered. Increased familiarity with genetic engineering techniques and advances in molecular analysis techniques have provided us with a greater understanding of the nature and impact of genetic changes in plants, and this can be used to refine pre-market assessments of genetically engineered plants and food and feeds derived from genetically engineered plants.

Indexed as

Genetic EngineeringBreedingCytoplasmDNA End-Joining RepairDNA Transposable ElementsGenome, PlantPlants, Genetically ModifiedDNA Transposable Elements

Identifiers

PMID25344849
PMCPMC4274372
OpenAlexW1989334757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.