ArticleBMC genomics2014
Small RNAs from plants, bacteria and fungi within the order Hypocreales are ubiquitous in human plasma.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Novel insights regarding the role of noncoding RNAs in diabetes.World journal of diabetes · 2023Review
- A tRNA-derived fragment present in E. coli OMVs regulates host cell gene expression and proliferation.PLoS pathogens · 2022Article
- Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts.International journal of molecular sciences · 2022Review
- MicroRNAs: Harbingers and shapers of periodontal inflammation.Seminars in cell & developmental biology · 2022Review
- Exosomes provide unappreciated carrier effects that assist transfers of their miRNAs to targeted cells; I. They are 'The Elephant in the Room'.RNA biology · 2021Review
- Breed differences in the expression levels of gga-miR-222a in laying hens influenced HMicrobiome · 2021Article
- Suppression ofFrontiers in molecular biosciences · 2021Article
- Extracellular RNAs in Bacterial Infections: From Emerging Key Players on Host-Pathogen Interactions to Exploitable Biomarkers and Therapeutic Targets.International journal of molecular sciences · 2020Review
- Circulating microbial small RNAs are altered in patients with rheumatoid arthritis.Annals of the rheumatic diseases · 2020Article
- Delineating effect of corn microRNAs and matrix, ingested as whole food, on gut microbiota in a rodent model.Food science & nutrition · 2020Article
- Article
- Gut microbiota: a new player in regulating immune- and chemo-therapy efficacy.Cancer drug resistance (Alhambra, Calif.) · 2020Article
- Extracellular Vesicles in Fungi: Past, Present, and Future Perspectives.Frontiers in cellular and infection microbiology · 2020Review
- Xeno-miRNA in Maternal-Infant Immune Crosstalk: An Aid to Disease Alleviation.Frontiers in immunology · 2020Review
- Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease.Cell metabolism · 2019Review
- Dietary microRNA-A Novel Functional Component of Food.Advances in nutrition (Bethesda, Md.) · 2019Review
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects.PloS one · 2019Article
- Small RNA profiling of low biomass samples: identification and removal of contaminants.BMC biology · 2018Article
- Extensive Degradation and Low Bioavailability of Orally Consumed Corn miRNAs in Mice.Nutrients · 2018Article
- RNase H2-Dependent Polymerase Chain Reaction and Elimination of Confounders in Sample Collection, Storage, and Analysis Strengthen Evidence That microRNAs in Bovine Milk Are Bioavailable in Humans.The Journal of nutrition · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe human microbiome plays a significant role in maintaining normal physiology. Changes in its composition have been associated with bowel disease, metabolic disorders and atherosclerosis. Sequences of microbial origin have been observed within small RNA sequencing data obtained from blood samples. The aim of this study was to characterise the microbiome from which these sequences are derived.
resultsAbundant non-human small RNA sequences were identified in plasma and plasma exosomal samples. Assembly of these short sequences into longer contigs was the pivotal novel step in ascertaining their origin by BLAST searches. Most reads mapped to rRNA sequences. The taxonomic profiles of the microbes detected were very consistent between individuals but distinct from microbiomes reported at other sites. The majority of bacterial reads were from the phylum Proteobacteria, whilst for 5 of 6 individuals over 90% of the more abundant fungal reads were from the phylum Ascomycota; of these over 90% were from the order Hypocreales. Many contigs were from plants, presumably of dietary origin. In addition, extremely abundant small RNAs derived from human Y RNAs were detected.
conclusionsA characteristic profile of a subset of the human microbiome can be obtained by sequencing small RNAs present in the blood. The source and functions of these molecules remain to be determined, but the specific profiles are likely to reflect health status. The potential to provide biomarkers of diet and for the diagnosis and prognosis of human disease is immense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.