ArticleBMC genomics2014
Human-induced evolution caught in action: SNP-array reveals rapid amphi-atlantic spread of pesticide resistance in the salmon ecotoparasite Lepeophtheirus salmonis.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Delousing performance of ballan wrasse (Labrus bergylta) and lumpfish (Cyclopterus lumpus): seasonal consistency and the challenge of cryptic lice for lumpfish.Pest management science · 2026Article
- Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene.Evolutionary applications · 2026Article
- Modelling the Effectiveness of Gene-Edited Salmon at Sea Lice Control and the Use of Refugia to Mitigate Counter-Adaptation.Evolutionary applications · 2025Article
- QTL mapping provides new insights into emamectin benzoate resistance in salmon lice, Lepeophtheirus salmonis.BMC genomics · 2024Article
- Insights from Hi-C data regarding the Pacific salmon louse (Lepeophtheirus salmonis) sex chromosomes.G3 (Bethesda, Md.) · 2024Article
- Article
- Evolutionary predictions for a parasite metapopulation: Modelling salmon louse resistance to pest controls in aquaculture.Evolutionary applications · 2023Article
- Aquaculture-driven evolution of the salmon louse mtDNA genome.Evolutionary applications · 2023Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- A modeling study of the impact of treatment policies on the evolution of resistance in sea lice on salmon farms.PloS one · 2023Article
- An update of the salmon louse (Lepeophtheirus salmonis) reference genome assembly.G3 (Bethesda, Md.) · 2022Article
- The salmon louse genome may be much larger than sequencing suggests.Scientific reports · 2022Article
- IIb-RAD-sequencing coupled with random forest classification indicates regional population structuring and sex-specific differentiation in salmon lice (Ecology and evolution · 2022Article
- Genomic analysis of the carboxylesterase family in the salmon louse (Lepeophtheirus salmonis).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Not that clean: Aquaculture-mediated translocation of cleaner fish has led to hybridization on the northern edge of the species' range.Evolutionary applications · 2021Article
- The potential for cleaner fish-driven evolution in the salmon louseEcology and evolution · 2021Article
- Losing the 'arms race': multiresistant salmon lice are dispersed throughout the North Atlantic Ocean.Royal Society open science · 2021Article
- Genetic response to human-induced habitat changes in the marine environment: A century of evolution of European sprat in Landvikvannet, Norway.Ecology and evolution · 2021Article
- Community Parameters and Genome-Wide RAD-Seq Loci ofPathogens (Basel, Switzerland) · 2021Article
- Migratory hosts can maintain the high-dose/refuge effect in a structured host-parasite system: The case of sea lice and salmon.Evolutionary applications · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe salmon louse, Lepeophtheirus salmonis, is an ectoparasite of salmonids that causes huge economic losses in salmon farming, and has also been causatively linked with declines of wild salmonid populations. Lice control on farms is reliant upon a few groups of pesticides that have all shown time-limited efficiency due to resistance development. However, to date, this example of human-induced evolution is poorly documented at the population level due to the lack of molecular tools. As such, important evolutionary and management questions, linked to the development and dispersal of pesticide resistance in this parasite, remain unanswered. Here, we introduce the first Single Nucleotide Polymorphism (SNP) array for the salmon louse, which includes 6000 markers, and present a population genomic scan using this array on 576 lice from twelve farms distributed across the North Atlantic.
resultsOur results support the hypothesis of a single panmictic population of lice in the Atlantic, and importantly, revealed very strong selective sweeps on linkage groups 1 and 5. These sweeps included candidate genes potentially connected to pesticide resistance. After genotyping a further 576 lice from 12 full sibling families, a genome-wide association analysis established a highly significant association between the major sweep on linkage group 5 and resistance to emamectin benzoate, the most widely used pesticide in salmonid aquaculture for more than a decade.
conclusionsThe analysis of conserved haplotypes across samples from the Atlantic strongly suggests that emamectin benzoate resistance developed at a single source, and rapidly spread across the Atlantic within the period 1999 when the chemical was first introduced, to 2010 when samples for the present study were obtained. These results provide unique insights into the development and spread of pesticide resistance in the marine environment, and identify a small genomic region strongly linked to emamectin benzoate resistance. Finally, these results have highly significant implications for the way pesticide resistance is considered and managed within the aquaculture industry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.