ArticleBMC genomics2014
Unveiling nonessential gene deletions that confer significant morphological phenotypes beyond natural yeast strains.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Systematic data analysis pipeline for quantitative morphological cell phenotyping.Computational and structural biotechnology journal · 2024Review
- Application of unimodal probability distribution models for morphological phenotyping of budding yeast.FEMS yeast research · 2024Article
- Targeted Mutations Produce Divergent Characteristics in Pedigreed Sake Yeast Strains.Microorganisms · 2023Article
- High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds.NPJ systems biology and applications · 2022Article
- Article
- Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.PLoS biology · 2020Article
- Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress.Oxidative medicine and cellular longevity · 2019Article
- Article
- Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae.BMC genomics · 2018Article
- Testing the neutral hypothesis of phenotypic evolution.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Systematic analysis of CaMolecular biology of the cell · 2017Article
- Phenotypic Diagnosis of Lineage and Differentiation During Sake Yeast Breeding.G3 (Bethesda, Md.) · 2017Article
- Article
- Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species.G3 (Bethesda, Md.) · 2016Article
- Single-cell phenomics in budding yeast.Molecular biology of the cell · 2015Review
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3 authors.
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Abstract
backgroundPhenotypes are variable within species, with high phenotypic variation in the fitness and cell morphology of natural yeast strains due to genetic variation. A gene deletion collection of yeast laboratory strains also contains phenotypic variations, demonstrating the involvement of each gene and its specific function. However, to date, no study has compared the phenotypic variations between natural strains and gene deletion mutants in yeast.
resultsThe morphological variance was compared between 110 most distinct gene deletion strains and 36 typical natural yeast strains using a generalized linear model. The gene deletion strains had higher morphological variance than the natural strains. Thirty-six gene deletion mutants conferred significant morphological changes beyond that of the natural strains, revealing the importance of the genes with high genetic interaction and specific cellular functions for species conservation.
conclusionBased on the morphological analysis, we discovered gene deletion mutants whose morphologies were not seen in nature. Our multivariate approach to the morphological diversity provided a new insight into the evolution and species conservation of yeast.
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