Evidence map›Paper›PMID 25344629›Full record

Trial reportNature neuroscience2014

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.

Adam M Brickman, Usman A Khan, Frank A Provenzano, Lok-Kin Yeung, Wendy Suzuki, Hagen Schroeter, Melanie Wall, Richard P Sloan, Scott A Small

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 169 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 11 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02312310 nacompletednot on this mapstarted 2015, after this paper: background citation

Dietary Cocoa Flavanols and Age-Related Memory Decline

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2015 to 2020Enrolled211ConditionsMemory LossArmsCocoa Flavanol
NCT03723694 nacompletednot on this mapstarted 2019, after this paper: background citation

Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders

TypeinterventionalSponsorColumbia UniversityRan2019 to 2023Enrolled259ConditionsMemory Loss, InflammationArms650 mg of Cocoapro flavanols, 0 mg of Cocoapro flavanols
NCT04582617 nacompletednot on this mapstarted 2016, after this paper: background citation

COSMOS Web: Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online

TypeinterventionalSponsorColumbia UniversityRan2016 to 2020Enrolled3,959ConditionsAging, Cognitive ChangeArmsCocoa Extract, Cocoa Extract Placebo, Multivitamin, Multivitamin placebo
3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 11 syntheses or guidelines pooled it, 340 citations in OpenAlex.

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  6. Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022
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  12. Feasibility of lifestyle interventions for cognition in adults with low education.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Adam M Brickman1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Department of Neurology, Columbia University, New York, New York, USA.
Usman A Khan1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Department of Neurology, Columbia University, New York, New York, USA.
Frank A Provenzano1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Department of Neurology, Columbia University, New York, New York, USA.
Lok-Kin Yeung1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Department of Neurology, Columbia University, New York, New York, USA.
Wendy SuzukiCenter for Neural Science, New York University, New York, New York, USA.
Hagen SchroeterMARS Inc., McLean, Virginia, USA.
Melanie Wall1] Department of Psychiatry, Columbia University, New York, New York, USA. [2] New York State Psychiatric Institute, New York, New York, USA.
Richard P Sloan1] Department of Psychiatry, Columbia University, New York, New York, USA. [2] New York State Psychiatric Institute, New York, New York, USA.
Scott A Small1] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA. [2] Department of Neurology, Columbia University, New York, New York, USA. [3] Department of Psychiatry, Columbia University, New York, New York, USA. [4] Department of Radiology, Columbia University, New York, New York, USA.
Columbia University · USMars (United States) · USNew York University · US

Funding

Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
MRI and mouse models of Alzheimer's disease and agingR01AG025161 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL, SCOTT A · 2005 to 2015
$3.0M
Exercise, Age-Related Memory Decline, and Hippocampal Function.R01AG035015 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SLOAN, RICHARD P, SMALL, SCOTT A · 2010 to 2014
$2.9M
Neural and Behavioral Profiles of Cognitive AgingR01AG034618 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL, SCOTT A · 2009 to 2013
$1.8M
NIA NIH HHS AG025161NIA NIH HHS AG034618NIA NIH HHS AG035015NIA NIH HHS AG08702NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG025161NIA NIH HHS R01 AG034618NIA NIH HHS R01 AG035015
6 · The paper itself

Abstract

The dentate gyrus (DG) is a region in the hippocampal formation whose function declines in association with human aging and is therefore considered to be a possible source of age-related memory decline. Causal evidence is needed, however, to show that DG-associated memory decline in otherwise healthy elders can be improved by interventions that enhance DG function. We addressed this issue by first using a high-resolution variant of functional magnetic resonance imaging (fMRI) to map the precise site of age-related DG dysfunction and to develop a cognitive task whose function localized to this anatomical site. Then, in a controlled randomized trial, we applied these tools to study healthy 50-69-year-old subjects who consumed either a high or low cocoa flavanol-containing diet for 3 months. A high-flavanol intervention was found to enhance DG function, as measured by fMRI and by cognitive testing. Our findings establish that DG dysfunction is a driver of age-related cognitive decline and suggest non-pharmacological means for its amelioration.

Indexed as

CacaoAcoustic StimulationAgedCognitionDentate GyrusDietExercise TestFemaleFlavanonesHumansMagnetic Resonance ImagingMaleMiddle AgedTime FactorsFlavanones

Identifiers

PMID25344629
PMCPMC4940121
OpenAlexW2146263384

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.