ReviewThe Plant cell2014
Plant metabolic modeling: achieving new insight into metabolism and metabolic engineering.
Review in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- A Guide to Metabolic Network Modeling for Plant Biology.Plants (Basel, Switzerland) · 2025Review
- Reprogrammed Plant Metabolism During Viral Infections: Mechanisms, Pathways and Implications.Molecular plant pathology · 2025Review
- Biophysical modelling as a tool for advancing plant science and engineering.Frontiers in plant science · 2025Review
- Model-assisted analysis for tuning anthocyanin composition in grape berries.Annals of botany · 2023Article
- Elucidating the Mesocarp Drupe Transcriptome of Açai (International journal of molecular sciences · 2023Article
- Exploring synergies between plant metabolic modelling and machine learning.Computational and structural biotechnology journal · 2022Review
- Potential metabolic mechanisms for inhibited chloroplast nitrogen assimilation under high CO2.Plant physiology · 2021Article
- Multi-omics approaches explain the growth-promoting effect of the apocarotenoid growth regulator zaxinone in rice.Communications biology · 2021Article
- Recent Advances in Carbon and Nitrogen Metabolism in C3 Plants.International journal of molecular sciences · 2020Review
- Leaf Energy Balance Requires Mitochondrial Respiration and Export of Chloroplast NADPH in the Light.Plant physiology · 2019Article
- Evolutionary Diversification of Primary Metabolism and Its Contribution to Plant Chemical Diversity.Frontiers in plant science · 2019Review
- Hierarchical and Dynamic Regulation of Defense-Responsive Specialized Metabolism by WRKY and MYB Transcription Factors.Frontiers in plant science · 2019Article
- Putting primary metabolism into perspective to obtain better fruits.Annals of botany · 2018Review
- Recent advances and effective strategies in the discovery and applications of natural products.RSC advances · 2018Review
- Metabolic network modeling with model organisms.Current opinion in chemical biology · 2017Review
- Metabolic model of central carbon and energy metabolisms of growing Arabidopsis thaliana in relation to sucrose translocation.BMC plant biology · 2016Article
- Flux Balance Analysis of Plant Metabolism: The Effect of Biomass Composition and Model Structure on Model Predictions.Frontiers in plant science · 2016Article
- Modeling Rice Metabolism: From Elucidating Environmental Effects on Cellular Phenotype to Guiding Crop Improvement.Frontiers in plant science · 2016Review
- Inference and Prediction of Metabolic Network Fluxes.Plant physiology · 2015Article
- Metabolic Architecture of the Cereal Grain and Its Relevance to Maximize Carbon Use Efficiency.Plant physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Models are used to represent aspects of the real world for specific purposes, and mathematical models have opened up new approaches in studying the behavior and complexity of biological systems. However, modeling is often time-consuming and requires significant computational resources for data development, data analysis, and simulation. Computational modeling has been successfully applied as an aid for metabolic engineering in microorganisms. But such model-based approaches have only recently been extended to plant metabolic engineering, mainly due to greater pathway complexity in plants and their highly compartmentalized cellular structure. Recent progress in plant systems biology and bioinformatics has begun to disentangle this complexity and facilitate the creation of efficient plant metabolic models. This review highlights several aspects of plant metabolic modeling in the context of understanding, predicting and modifying complex plant metabolism. We discuss opportunities for engineering photosynthetic carbon metabolism, sucrose synthesis, and the tricarboxylic acid cycle in leaves and oil synthesis in seeds and the application of metabolic modeling to the study of plant acclimation to the environment. The aim of the review is to offer a current perspective for plant biologists without requiring specialized knowledge of bioinformatics or systems biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.