ArticleBMC infectious diseases2014
Cryptosporidium andersoni as a novel predominant Cryptosporidium species in outpatients with diarrhea in Jiangsu Province, China.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- A retrospective epidemiological analysis of human Cryptosporidium infection in China during the past three decades (1987-2018).PLoS neglected tropical diseases · 2020Pooled it
- Prevalence and molecular characterisation ofInternational journal for parasitology. Parasites and wildlife · 2026Article
- Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review.Veterinary sciences · 2025Review
- Molecular analysis of cryptosporidiosis on cattle farms in Gran Canaria, Canary Islands (Spain).International journal of veterinary science and medicine · 2025Article
- Food and Waterborne Cryptosporidiosis from a One Health Perspective: A Comprehensive Review.Animals : an open access journal from MDPI · 2024Review
- Molecular detection and genetic variability ofHeliyon · 2024Article
- Cryptosporidium spp. in large-scale sheep farms in China: prevalence and genetic diversity.Scientific reports · 2024Article
- Molecular characterization and zoonotic potential of Cryptosporidium spp. and Giardia duodenalis in humans and domestic animals in Heilongjiang Province, China.Parasites & vectors · 2024Article
- Study on genetic characteristics of Cryptosporidium isolates and first report of C. parvum IIdA24G2 subtype in dairy cattle in China.Parasitology research · 2024Article
- Molecular characterization ofFrontiers in veterinary science · 2024Article
- Molecular Detection and Genotyping of Cryptosporidium spp. Isolates from Bats in Colombia.Acta parasitologica · 2023Article
- First report ofFrontiers in veterinary science · 2023Article
- Genetic characterizations ofOne health (Amsterdam, Netherlands) · 2021Article
- Prevalence of Toxoplasma gondii and Cryptosporidium in Feral and Farmed American Mink (Neovison vison) in Denmark.Acta parasitologica · 2021Article
- An Update on ZoonoticAnimals : an open access journal from MDPI · 2021Review
- ZoonoticMicroorganisms · 2021Article
- Occurrence and molecular characterization of Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi, and Blastocystis sp. in captive wild animals in zoos in Henan, China.BMC veterinary research · 2021Article
- Prevalence and multilocus genotyping of Cryptosporidium spp. in cattle in Jiangxi Province, southeastern China.Parasitology research · 2021Article
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- An annotated checklist of the eukaryotic parasites of humans, exclusive of fungi and algae.ZooKeys · 2021Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryptosporidium hominis and C. parvum are usually considered to be the major pathogens responsible for human cryptosporidiosis. However, there have been few studies regarding the molecular epidemiology of Cryptosporidium in human infections in China. Here we investigated Cryptosporidium infection in patients with diarrhea, in Danyang Hospital of Jiangsu Province, China, at the genotype level.
methodsA total of 232 stool specimens were collected from outpatients with diarrhea in Danyang Hospital of Jiangsu Province, China, from February 2012 to January 2013. Each specimen was stained from direct fecal smears and examined for Cryptosporidium using modified acid fast staining and microscopy. Moreover, genomic DNA of each fecal sample was screened for the presence of Cryptosporidium with nested PCR, which was genotyped by analyzing the DNA sequences of small subunit rRNA (SSU rRNA).
resultsThe average infection rate of Cryptosporidium was 1.3% (3/232) by microscopy and subjected to PCR amplification of the SSU rRNA gene of Cryptosporidium, with 9.91% (23/232) being positive for Cryptosporidium with a significant peak in autumn. Based on the SSU rRNA gene, two Cryptosporidium spp. were identified, including C. andersoni (n =21) and C. hominis (n =2). Two types of C. andersoni, designated as A370 + and A370 - , were found in the SSU rRNA gene in our present study, which was 100% homologous to C. andersoni infections derived from dairy calves and goats, respectively. The clinical questionnaires showed no significant difference in age, gender and frequency of diarrhea, but duration of diarrhea was shorter for C. andersoni than that of C. hominis (mean, 2 vs. 4 days; p <0.01).
conclusionsC. andersoni is the dominant species in Danyang City of Jiangsu Province. The fact that SSU rRNA sequences of C. andersoni obtained from human stools exhibited 100% homologous to those derived from dairy calves and goats supported that C. andersoni infection might be attributable to animal origin. The difference in the duration of diarrhea of C. andersoni and C. hominis indicated that different Cryptosporidium species might cause different clinical manifestations.
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