ArticleMolecular neurobiology2015
Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Astrocyte polarization in glaucoma: a new opportunity.Neural regeneration research · 2022Review
- The heterogeneity of astrocytes in glaucoma.Frontiers in neuroanatomy · 2022Review
- Gynostemma Glycosides Protect Retinal Ganglion Cells in Rats with Chronic High Intraocular Pressure by Regulating the STAT3/JAK2 Signaling Pathway and Inhibiting Astrocyte and Microglia Activation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- MicroRNA-93/STAT3 signalling pathway mediates retinal microglial activation and protects retinal ganglion cells in an acute ocular hypertension model.Cell death & disease · 2021Article
- Article
- Essential thrombocytosis attributed to JAK2-T875N germline mutation.International journal of hematology · 2019Article
- Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease.Scientific reports · 2018Article
- Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries.The Journal of experimental medicine · 2017Article
- Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2017Article
- Pioglitazone ameliorates retinal ischemia/reperfusion injuryInternational journal of ophthalmology · 2017Article
- Wogonin prevents TLR4-NF-κB-medicated neuro-inflammation and improves retinal ganglion cells survival in retina after optic nerve crush.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes play an important role in the pathogenesis of glaucoma. Abnormal activation and/or proliferation of astrocytes, termed astrogliosis, have been observed during optic nerve degeneration. Our previous study identified signal transducer and activator of transcription 3 (STAT3) signaling as an important regulator of astrogliosis in the optic nerve in a rat transient ischemia/reperfusion model. In this study, we used pharmacological inhibition of STAT3 activation in the same model to assess whether it could attenuate reactive astrogliosis and to observe its influence on optic nerve damage and retinal ganglion cell (RGC) damage. Our findings show that retrobulbar inhibition of STAT3 in optic nerve head astrocytes leads to (a) increased nerve fiber bundle survival in the optic nerve, (b) increased nerve fiber bundle and RGC survival in the retina, (c) decreased astrocyte reactivation in the optic nerve (d) decreased remodeling of astrocytes in the optic nerve, and (e) no influence of astrocyte reactivation inside the retina. Taken together, the Janus kinase/STAT3 pathway contributes to astrocyte reactivation in the optic nerve, which plays a pivotal role in neurodegeneration after transient ischemia/reperfusion in vivo. Inhibition of this pathway provides a potential therapeutic strategy for the treatment of glaucomatous neuropathy, and could extend to other neurodegenerative diseases.
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Registered trials
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