ArticleWorld journal of microbiology & biotechnology2015
Cyclic dipeptides produced by fungus Eupenicillium brefeldianum HMP-F96 induced extracellular alkalinization and H2O 2 production in tobacco cell suspensions.
Article in World journal of microbiology & biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Elicitor-mediated enhancement of secondary metabolites in plant species: a review.Frontiers in plant science · 2025Review
- 2,5-Diketopiperazines: A Review of Source, Synthesis, Bioactivity, Structure, and MS Fragmentation.Current medicinal chemistry · 2023Review
- Metabolite Chemical Composition of theMycobiology · 2023Article
- Plant immunity inducers: from discovery to agricultural application.Stress biology · 2022Review
- Article
- Rapid Screening and Identification of Antitumor Ingredients from the Mangrove Endophytic Fungus Using an Enzyme-Immobilized Magnetic Nanoparticulate System.Molecules (Basel, Switzerland) · 2021Article
- Melatonin and Its Homologs Induce Immune ResponsesFrontiers in plant science · 2021Article
- Biotic elicitors enhance diosgenin production inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity.Molecules (Basel, Switzerland) · 2017Review
- Release of free amino acids upon oxidation of peptides and proteins by hydroxyl radicals.Analytical and bioanalytical chemistry · 2017Article
- Induction of systemic disease resistance in Nicotiana benthamiana by the cyclodipeptides cyclo (l-Pro-l-Pro) and cyclo (d-Pro-d-Pro).Molecular plant pathology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular alkalinization and H2O2 production are important early events during induced systemic resistance (ISR) establishment in plants. In a screen for metabolites as potential ISR activators from 98 fungal isolates associated with marine sponge Hymeniacidon perleve, the crude metabolites of fungus Eupenicillium brefeldianum HMP-F96 induced significant extracellular alkalinization coupled with H2O2 production in tobacco cell suspensions. A combined bioactivity and (1)H NMR-guided fractionation approach was used to disclose the chemical determinants responsible for the activities. Eight cyclic dipeptides were purified from the fermentation broth of the strain and were structurally characterized by NMR and MS experiments. This study represents the first report of the occurrence of cyclic dipeptides in E. brefeldianum and of their activities of inducing extracellular alkalinization and H2O2 production in tobacco cell suspensions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.