Trial reportAmerican journal of physiology. Lung cellular and molecular physiology2014
Cigarette smoke enhances proliferation and extracellular matrix deposition by human fetal airway smooth muscle.
Trial report in American journal of physiology. Lung cellular and molecular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Dysregulated iron metabolism in remodeling of aging asthmatic human airways.American journal of physiology. Cell physiology · 2026Article
- Smoking and endometriosis: A narrative review.Tobacco induced diseases · 2025Review
- Pharmacological therapy for stable chronic obstructive pulmonary disease.Chronic diseases and translational medicine · 2023Review
- The effects of dual IQOS and cigarette smoke exposure on airway epithelial cells: implications for lung health and respiratory disease pathogenesis.ERJ open research · 2023Article
- How does cigarette smoking affect airway remodeling in asthmatics?Tobacco induced diseases · 2023Review
- HDAC6 Activates ERK in Airway and Pulmonary Vascular Remodeling of Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2021Article
- Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle.Archives of biochemistry and biophysics · 2021Article
- Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non-asthmatic airway smooth muscle cells is similar.Journal of cellular and molecular medicine · 2021Article
- Cigarette Smoke Exposure, Pediatric Lung Disease, and COVID-19.Frontiers in physiology · 2021Review
- Progress in the mechanism and targeted drug therapy for COPD.Signal transduction and targeted therapy · 2020Review
- TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases.Frontiers in medicine · 2020Review
- Differential estrogen-receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodelingFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Moderate hyperoxia induces senescence in developing human lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells.American journal of respiratory cell and molecular biology · 2019Article
- CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.JCI insight · 2019Article
- IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette.ERJ open research · 2019Article
- Contribution of programmed cell death 6 genetic variations, gender, and smoking status to lung cancer.OncoTargets and therapy · 2019Article
- RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation.Journal of cell science · 2018Article
- The Interplay Between Immune Response and Bacterial Infection in COPD: Focus Upon Non-typeableFrontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Cigarette smoke is a common environmental insult associated with increased risk of developing airway diseases such as wheezing and asthma in neonates and children. In adults, asthma involves airway remodeling characterized by increased airway smooth muscle (ASM) cell proliferation and increased extracellular matrix (ECM) deposition, as well as airway hyperreactivity. The effects of cigarette smoke on remodeling and contractility in the developing airway are not well-elucidated. In this study, we used canalicular-stage (18-20 wk gestational age) human fetal airway smooth muscle (fASM) cells as an in vitro model of the immature airway. fASM cells were exposed to cigarette smoke extract (CSE; 0.5-1.5% for 24-72 h), and cell proliferation, ECM deposition, and intracellular calcium ([Ca(2+)]i) responses to agonist (histamine 10 μM) were used to evaluate effects on remodeling and hyperreactivity. CSE significantly increased cell proliferation and deposition of ECM molecules collagen I, collagen III, and fibronectin. In contrast, [Ca(2+)]i responses were not significantly affected by CSE. Analysis of key signaling pathways demonstrated significant increase in extracellular signal-related kinase (ERK) and p38 activation with CSE. Inhibition of ERK or p38 signaling prevented CSE-mediated changes in proliferation, whereas only ERK inhibition attenuated the CSE-mediated increase in ECM deposition. Overall, these results demonstrate that cigarette smoke may enhance remodeling in developing human ASM through hyperplasia and ECM production, thus contributing to development of neonatal and pediatric airway disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.