ArticleJournal of the American Chemical Society2014
Discovery of catalytic phages by biocatalytic self-assembly.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Site-selective peptide bond hydrolysis and ligation in water by short peptide-based assemblies.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Manually curated dataset of catalytic peptides for ester hydrolysis.Data in brief · 2023Article
- Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups.ACS applied bio materials · 2023Review
- Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers.ACS central science · 2022Article
- Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity.Chemical science · 2021Article
- Biocatalysts Based on Peptide and Peptide Conjugate Nanostructures.Biomacromolecules · 2021Review
- Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids.Chembiochem : a European journal of chemical biology · 2021Article
- Tripeptide Self-Assembly into Bioactive Hydrogels: Effects of Terminus Modification on Biocatalysis.Molecules (Basel, Switzerland) · 2020Article
- Article
- Synergistic Interactions Are Prevalent in Catalytic Amyloids.Chembiochem : a European journal of chemical biology · 2020Article
- Biocatalysis of D,L-Peptide Nanofibrillar Hydrogel.Molecules (Basel, Switzerland) · 2020Article
- Article
- Catalytic peptide assemblies.Chemical Society reviews · 2018Review
- Design of Polyproline-Based Catalysts for Ester Hydrolysis.ACS omega · 2017Article
- Short Self-Assembling Peptides Are Able to Bind to Copper and Activate Oxygen.Angewandte Chemie (International ed. in English) · 2016Article
- Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches.Annual review of biomedical engineering · 2016Review
- Chemically Modifying Viruses for Diverse Applications.ACS chemical biology · 2016Review
- Biomimetic Crystallization of MnFeChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2016Article
- Fast, cheap and out of control--Insights into thermodynamic and informatic constraints on natural protein sequences from de novo protein design.Biochimica et biophysica acta · 2016Article
- Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells.Journal of the American Chemical Society · 2016Article
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Authors and funding
11 authors.
Funding
Abstract
Discovery of new catalysts for demanding aqueous reactions is challenging. Here, we describe methodology for selection of catalytic phages by taking advantage of localized assembly of the product of the catalytic reaction that is screened for. A phage display library covering 10(9) unique dodecapeptide sequences is incubated with nonassembling precursors. Phages which are able to catalyze formation of the self-assembling reaction product (via amide condensation) acquire an aggregate of reaction product, enabling separation by centrifugation. The thus selected phages can be amplified by infection of Escherichia coli. These phages are shown to catalyze amide condensation and hydrolysis. Kinetic analysis shows a minor role for substrate binding. The approach enables discovery and mass-production of biocatalytic phages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.