Evidence map›Paper›PMID 25343505›Full record

ArticlePloS one2014

Validation of cell-cycle arrest biomarkers for acute kidney injury after pediatric cardiac surgery.

Melanie Meersch, Christoph Schmidt, Hugo Van Aken, Jan Rossaint, Dennis Görlich, Dirk Stege, Edward Malec, Katarzyna Januszewska, Alexander Zarbock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 4 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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  9. Early Diagnosis of Pediatric Acute Kidney Injury: An Achievable Goal?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Melanie MeerschDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Christoph SchmidtDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Hugo Van AkenDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Jan RossaintDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
Dennis GörlichInstitute of Biostatistics and Clinical Research, University of Münster, Münster, Germany.
Dirk StegeDepartment of Pediatric Cardiology, University of Münster, Münster, Germany.
Edward MalecDepartment of Pediatric Heart Surgery, University of Münster, Münster, Germany.
Katarzyna JanuszewskaDepartment of Pediatric Heart Surgery, University of Münster, Münster, Germany.
Alexander ZarbockDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany.
University of Münster · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe lack of early biomarkers for acute kidney injury (AKI) seriously inhibits the initiation of preventive and therapeutic measures for this syndrome in a timely manner. We tested the hypothesis that insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers of G1 cell cycle arrest, function as early biomarkers for AKI after congenital heart surgery with cardiopulmonary bypass (CPB).

methodsWe prospectively studied 51 children undergoing cardiac surgery with CPB. Serial urine samples were analyzed for [TIMP-2]•[IGFBP7]. The primary outcome measure was AKI defined by the pRIFLE criteria within 72 hours after surgery.

results12 children (24%) developed AKI within 1.67 (SE 0.3) days after surgery. Children who developed AKI after cardiac surgery had a significant higher urinary [TIMP-2]•[IGFBP7] as early as 4 h after the procedure, compared to children who did not develop AKI (mean of 1.93 ((ng/ml)²/1000) (SE 0.4) vs 0.47 ((ng/ml)²/1000) (SE 0.1), respectively; p<0.05). Urinary [TIMP-2]•[IGFBP7] 4 hours following surgery demonstrated an area under the receiver-operating characteristic curve of 0.85. Sensitivity was 0.83, and specificity was 0.77 for a cutoff value of 0.70 ((ng/ml)²/1000).

conclusionsUrinary [TIMP-2]•[IGFBP7] represent sensitive, specific, and highly predictive early biomarkers for AKI after surgery for congenital heart disease.

trial registrationwww.germanctr.de/, DRKS00005062.

Indexed as

Cell Cycle CheckpointsAcute Kidney InjuryBiomarkersCardiac Surgical ProceduresChildFemaleHumansInsulin-Like Growth Factor Binding ProteinsMalePediatricsProportional Hazards ModelsROC CurveTissue Inhibitor of Metalloproteinase-2Biomarkersinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsTissue Inhibitor of Metalloproteinase-2

Identifiers

PMID25343505
PMCPMC4208780
OpenAlexW2018929755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.