Evidence map›Paper›PMID 25343448›Full record

ArticlePloS one2014

Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae strains carried by children infected with human immunodeficiency virus.

Dodi Safari, Nia Kurniati, Lia Waslia, Miftahuddin Majid Khoeri, Tiara Putri, Debby Bogaert, Krzysztof Trzciński

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Dodi SafariEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Nia KurniatiDepartment of Child Health, Dr. Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Lia WasliaEijkman Oxford Clinical Research Unit, Jakarta, Indonesia.
Miftahuddin Majid KhoeriEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Tiara PutriFaculty of Biology, Gajah Mada University, Yogyakarta, Indonesia.
Debby BogaertDepartment of Pediatric Immunology and Infectious Diseases, Wilhelmina?s Children Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Krzysztof TrzcińskiDepartment of Pediatric Immunology and Infectious Diseases, Wilhelmina?s Children Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Eijkman Institute for Molecular Biology · IDWilhelmina Children's Hospital · NLUniversitas Gadjah Mada · IDUniversity of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe studied the serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae isolates carried by children infected with HIV in Jakarta, Indonesia.

methodsNasopharyngeal swabs were collected from 90 HIV infected children aged 4 to 144 months. S. pneumoniae was identified by conventional and molecular methods. Serotyping was performed with sequential multiplex PCR and antibiotic susceptibility with the disk diffusion method.

resultsWe identified S. pneumoniae carriage in 41 children (46%). Serotype 19 F was most common among 42 cultured strains (19%) followed by 19 A and 6A/B (10% each), and 23 F (7%). Most isolates were susceptible to chloramphenicol (86%), followed by clindamycin (79%), erythromycin (76%), tetracycline (43%), and sulphamethoxazole/trimethoprim (41%). Resistance to penicillin was most common with only 33% of strains being susceptible. Strains of serotypes targeted by the 13-valent pneumococcal conjugate polysaccharide vaccine (PCV13) were more likely to be multidrug resistant (13 of 25 or 52%) compared to non-PCV13 serotype isolates (3 of 17 or 18%; Fisher exact test p = 0.05).

conclusionOur study provides insight into the epidemiology of pneumococcal carriage in young HIV patients in Indonesia. These findings may facilitate potential preventive strategies that target invasive pneumococcal disease in Indonesia.

Indexed as

Anti-Bacterial AgentsCarrier StateChildChild, PreschoolDrug Resistance, Multiple, BacterialFemaleHIV InfectionsHumansIndonesiaInfantInfant, NewbornMaleMicrobial Sensitivity TestsSerotypingStreptococcus pneumoniaeAnti-Bacterial Agents

Identifiers

PMID25343448
PMCPMC4208773
OpenAlexW2042511011

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.