ArticleACS applied materials & interfaces2014
Janus particles as artificial antigen-presenting cells for T cell activation.
Article in ACS applied materials & interfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Decoding mechanoregulation in immunological synapses using biomimetic artificial cells.Nature methods · 2026Article
- Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies.Nature biomedical engineering · 2024Article
- Adaptive immunity of materials: Implications for tissue healing and regeneration.Bioactive materials · 2024Review
- Multimodal probing of T-cell recognition with hexapod heterostructures.Nature methods · 2024Article
- Janus Droplet Formation via Thermally Induced Phase Separation: A Numerical Model with Diffusion and Convection.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Lipid Phase Separation in Vesicles Enhances TRAIL-Mediated Cytotoxicity.Nano letters · 2022Article
- Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Janus Particles at Fluid Interfaces: Stability and Interfacial Rheology.Nanomaterials (Basel, Switzerland) · 2021Review
- Bifunctional Janus Particles as Multivalent Synthetic Nanoparticle Antibodies (SNAbs) for Selective Depletion of Target Cells.Nano letters · 2021Article
- Janus particles: design, preparation, and biomedical applications.Materials today. Bio · 2019Review
- Characteristics of microcontact printing with polyelectrolyte ink for the precise preparation of patches on silica particles.RSC advances · 2018Article
- Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications.Chemical Society reviews · 2018Review
- From 2D to 3D patches on multifunctional particles: how microcontact printing creates a new dimension of functionality.Soft matter · 2018Article
- Janus Nanoparticles for T Cell Activation: Clustering Ligands to Enhance Stimulation.Journal of materials chemistry. B · 2017Article
- Surface engineering for lymphocyte programming.Advanced drug delivery reviews · 2017Review
- T cell immunoengineering with advanced biomaterials.Integrative biology : quantitative biosciences from nano to macro · 2017Review
- Interrogating Cellular Functions with Designer Janus Particles.Chemistry of materials : a publication of the American Chemical Society · 2017Article
- A Liquid-Handling Robot for Automated Attachment of Biomolecules to Microbeads.Journal of laboratory automation · 2016Article
- Janus particles for biological imaging and sensing.The Analyst · 2016Review
- Remote Control of T Cell Activation Using Magnetic Janus Particles.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Here we show that the multifunctionality of Janus particles can be exploited for in vitro T cell activation. We engineer bifunctional Janus particles on which the spatial distribution of two ligands, anti-CD3 and fibronectin, mimics the "bull's eye" protein pattern formed in the membrane junction between a T cell and an antigen-presenting cell. Different levels of T cell activation can be achieved by simply switching the spatial distribution of the two ligands on the surfaces of the "bull's eye" particles. We find that the ligand pattern also affects clustering of intracellular proteins. This study demonstrates that anisotropic particles, such as Janus particles, can be developed as artificial antigen-presenting cells for modulating T cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.