ArticleJournal of therapeutic ultrasound2014
Treatment envelope evaluation in transcranial magnetic resonance-guided focused ultrasound utilizing 3D MR thermometry.
Article in Journal of therapeutic ultrasound, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- A figure of merit for transcranial ultrasound transmission based on coupled elastic-thermal analysis.Physics in medicine and biology · 2025Article
- In vivo simultaneous proton resonance frequency shift thermometry and single reference variable flip angle TMagnetic resonance in medicine · 2025Article
- Characterization of a Low-Profile, Flexible, and Acoustically Transparent Receive-Only MRI Coil Array for High Sensitivity MR-Guided Focused Ultrasound.IEEE access : practical innovations, open solutions · 2022Article
- Pilot study of focused ultrasound for drug-resistant epilepsy.Epilepsia · 2022Article
- Targeted manipulation of pain neural networks: The potential of focused ultrasound for treatment of chronic pain.Neuroscience and biobehavioral reviews · 2020Review
- Simultaneous multislice MRI thermometry with a single coil using incoherent blipped-controlled aliasing.Magnetic resonance in medicine · 2020Article
- Focused Ultrasound for Noninvasive, Focal Pharmacologic Neurointervention.Frontiers in neuroscience · 2020Review
- Low-rank plus sparse compressed sensing for accelerated proton resonance frequency shift MR temperature imaging.Magnetic resonance in medicine · 2019Article
- A spiral-based volumetric acquisition for MR temperature imaging.Magnetic resonance in medicine · 2018Article
- A dual-mode hemispherical sparse array for 3D passive acoustic mapping and skull localization within a clinical MRI guided focused ultrasound device.Physics in medicine and biology · 2018Article
- Spatially-segmented undersampled MRI temperature reconstruction for transcranial MR-guided focused ultrasound.Journal of therapeutic ultrasound · 2017Article
- MR thermometry for focused ultrasound monitoring utilizing model predictive filtering and ultrasound beam modeling.Journal of therapeutic ultrasound · 2016Article
- Model predictive filtering MR thermometry: Effects of model inaccuracies, k-space reduction factor, and temperature increase rate.Magnetic resonance in medicine · 2016Article
- Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS.Journal of therapeutic ultrasound · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCurrent clinical targets for transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) are all located close to the geometric center of the skull convexity, which minimizes challenges related to focusing the ultrasound through the skull bone. Non-central targets will have to be reached to treat a wider variety of neurological disorders and solid tumors. Treatment envelope studies utilizing two-dimensional (2D) magnetic resonance (MR) thermometry have previously been performed to determine the regions in which therapeutic levels of FUS can currently be delivered. Since 2D MR thermometry was used, very limited information about unintended heating in near-field tissue/bone interfaces could be deduced.
methodsIn this paper, we present a proof-of-concept treatment envelope study with three-dimensional (3D) MR thermometry monitoring of FUS heatings performed in a phantom and a lamb model. While the moderate-sized transducer used was not designed for transcranial geometries, the 3D temperature maps enable monitoring of the entire sonication field of view, including both the focal spot and near-field tissue/bone interfaces, for full characterization of all heating that may occur. 3D MR thermometry is achieved by a combination of k-space subsampling and a previously described temporally constrained reconstruction method.
resultsWe present two different types of treatment envelopes. The first is based only on the focal spot heating-the type that can be derived from 2D MR thermometry. The second type is based on the relative near-field heating and is calculated as the ratio between the focal spot heating and the near-field heating. This utilizes the full 3D MR thermometry data achieved in this study.
conclusionsIt is shown that 3D MR thermometry can be used to improve the safety assessment in treatment envelope evaluations. Using a non-optimal transducer, it is shown that some regions where therapeutic levels of FUS can be delivered, as suggested by the first type of envelope, are not necessarily safely treated due to the amount of unintended near-field heating occurring. The results presented in this study highlight the need for 3D MR thermometry in tcMRgFUS.
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