ArticleCurrent neuropharmacology2014
Pathological role for exocytotic glutamate release from astrocytes in hepatic encephalopathy.
Article in Current neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Resveratrol in Patients with Minimal Hepatic Encephalopathy.Nutrients · 2018Trial
- Guanosine Attenuates Astrocyte-Associated Glutamatergic Dysregulation and Improves Survival in Acute Liver Failure-Induced Hepatic Encephalopathy.Metabolites · 2026Article
- Pathological Roles of Astrocytes in Traumatic Brain Injury.CNS neuroscience & therapeutics · 2026Review
- Glutamine and Albumin Levels in Cerebrospinal Fluid Are Correlated with Neurological Severity in an Experimental Model of Acute Hepatic Encephalopathy.Metabolites · 2025Article
- Astrocytes in human central nervous system diseases: a frontier for new therapies.Signal transduction and targeted therapy · 2023Review
- Ceftriaxone as a Novel Therapeutic Agent for Hyperglutamatergic States: Bridging the Gap Between Preclinical Results and Clinical Translation.Frontiers in neuroscience · 2022Review
- Principles of Astrogliopathology.Advances in neurobiology · 2021Article
- Astroglia in Sepsis Associated Encephalopathy.Neurochemical research · 2020Review
- General Pathophysiology of Astroglia.Advances in experimental medicine and biology · 2019Review
- Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats.Frontiers in molecular neuroscience · 2019Article
- Exploration of the involvement of LncRNA in HIV-associated encephalitis using bioinformatics.PeerJ · 2018Article
- Diversity of astroglial responses across human neurodegenerative disorders and brain aging.Brain pathology (Zurich, Switzerland) · 2017Article
- Stratification of astrocytes in healthy and diseased brain.Brain pathology (Zurich, Switzerland) · 2017Article
- Article
- Translational potential of astrocytes in brain disorders.Progress in neurobiology · 2016Review
- The homeostatic astroglia emerges from evolutionary specialization of neural cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Volume-regulated anion channel--a frenemy within the brain.Pflugers Archiv : European journal of physiology · 2016Review
- Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders.Neurobiology of disease · 2016Article
- PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.Opera medica et physiologica · 2016Article
- Current Drug Managements of Wilson's Disease: From West to East.Current neuropharmacology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Liver failure can lead to generalized hyperammonemia, which is thought to be the underlying cause of hepatic encephalopathy. This neuropsychiatric syndrome is accompanied by functional changes of astrocytes. These glial cells enter ammonia-induced self-amplifying cycle characterized by brain oedema, oxidative and osmotic stress that causes modification of proteins and RNA. Consequently, protein expression and function are affected, including that of glutamine synthetase and plasmalemmal glutamate transporters, leading to glutamate excitotoxicity; Ca(2+)-dependent exocytotic glutamate release from astrocytes contributes to this extracellular glutamate overload.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.