ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Potential role of the airway wall in the asthma of obesity.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02953431 (Increased Lung Volume as Controller Therapy for Asthma), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Increased Lung Volume as Controller Therapy for Asthma
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Is Bariatric Surgery Better than Nonsurgical Weight Loss for Improving Asthma Control? A Systematic Review.Obesity surgery · 2021Pooled it
- The association between body mass index and asthma in children: a cross‑sectional study from NHANES 1999 to 2020.Scientific reports · 2025Article
- Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.Respiratory research · 2022Article
- Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity.Frontiers in physiology · 2022Article
- Clinical Characteristics and Management Strategies for Adult Obese Asthma Patients.Journal of asthma and allergy · 2022Review
- Positive expiratory pressure: a potential therapy to mitigate acute bronchoconstriction in the asthma of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Altered airway mechanics in the context of obesity and asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Physiological signature of late-onset nonallergic asthma of obesity.ERJ open research · 2020Article
- Obesity-induced asthma: Role of free fatty acid receptors.The Japanese dental science review · 2019Review
- Article
- Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet.Scientific reports · 2019Article
- The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Innate lymphoid cells at the interface between obesity and asthma.Immunology · 2018Review
- Pathophysiology to Phenotype in the Asthma of Obesity.Annals of the American Thoracic Society · 2017Review
- Chair's Summary: Obesity and Associated Changes in Metabolism, Implications for Lung Diseases.Annals of the American Thoracic Society · 2017Review
- An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease.Annals of the American Thoracic Society · 2017Article
- Systems physiology of the airways in health and obstructive pulmonary disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma.American journal of respiratory cell and molecular biology · 2016Article
- Phenotyping of difficult asthma using longitudinal physiological and biomarker measurements reveals significant differences in stability between clusters.BMC pulmonary medicine · 2016Article
- Physiological Mechanisms of Airway Hyperresponsiveness in Obese Asthma.American journal of respiratory cell and molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The pathogenesis of late-onset TH2-low asthma in obesity is thought to be related to weight-related decreases in lung volume, but why only a subset of individuals with obesity develop this condition is unknown. We tested the hypothesis that natural variations in both airway wall stiffness and airway wall thickness could lead to a subpopulation of hyperresponsive individuals exhibiting the symptoms of asthma in the setting of obesity. Increases in airway resistance (Raw) after airway smooth muscle stimulation were simulated using a computational model of an elastic airway embedded in elastic parenchyma. Using a range of randomly chosen values for both airway wall stiffness and thickness, we determined the resulting probability distributions of Raw responsiveness for a variety of different levels of transpulmonary pressure (Ptp). As Ptp decreased from 5 to 1 cmH2O, the resulting distributions of Raw moved toward progressively higher levels of responsiveness. With appropriate choices for the mean and standard deviation of the parameter that controls either airway wall stiffness or thickness, the model predicts a relationship between airway hyperresponsiveness and body mass index that is similar to that which has been reported in populations with obesity. We conclude that natural variations in airway wall mechanics and geometry between different individuals can potentially explain why an increasing percentage of the population exhibits the symptoms of asthma as the obesity of the population increases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.